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A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity.
Motazacker MM, Pirhonen J, van Capelleveen JC, Weber-Boyvat M, Kuivenhoven JA, Shah S, Hovingh GK, Metso J, Li S, Ikonen E, Jauhiainen M, Dallinga-Thie GM, Olkkonen VM. Motazacker MM, et al. Among authors: li s. Atherosclerosis. 2016 Jun;249:140-7. doi: 10.1016/j.atherosclerosis.2016.04.005. Epub 2016 Apr 11. Atherosclerosis. 2016. PMID: 27105157
OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism.
Kentala H, Koponen A, Vihinen H, Pirhonen J, Liebisch G, Pataj Z, Kivelä A, Li S, Karhinen L, Jääskeläinen E, Andrews R, Meriläinen L, Matysik S, Ikonen E, Zhou Y, Jokitalo E, Olkkonen VM. Kentala H, et al. Among authors: li s. Cell Mol Life Sci. 2018 Nov;75(21):4041-4057. doi: 10.1007/s00018-018-2850-8. Epub 2018 Jun 12. Cell Mol Life Sci. 2018. PMID: 29947926
Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.
Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JWR, Tontonoz P. Sandhu J, et al. Among authors: li s. Cell. 2018 Oct 4;175(2):514-529.e20. doi: 10.1016/j.cell.2018.08.033. Epub 2018 Sep 13. Cell. 2018. PMID: 30220461 Free PMC article.
Elevated levels of StAR-related lipid transfer protein 3 alter cholesterol balance and adhesiveness of breast cancer cells: potential mechanisms contributing to progression of HER2-positive breast cancers.
Vassilev B, Sihto H, Li S, Hölttä-Vuori M, Ilola J, Lundin J, Isola J, Kellokumpu-Lehtinen PL, Joensuu H, Ikonen E. Vassilev B, et al. Among authors: li s. Am J Pathol. 2015 Apr;185(4):987-1000. doi: 10.1016/j.ajpath.2014.12.018. Epub 2015 Feb 12. Am J Pathol. 2015. PMID: 25681734
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