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Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.
Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T. Hayashi I, et al. Among authors: li t. J Biol Chem. 2009 Oct 9;284(41):27838-27847. doi: 10.1074/jbc.M109.055061. Epub 2009 Aug 14. J Biol Chem. 2009. PMID: 19684016 Free PMC article.
S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.
Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, Thinakaran G. Cheng H, et al. Among authors: li t. J Biol Chem. 2009 Jan 16;284(3):1373-84. doi: 10.1074/jbc.M806380200. Epub 2008 Nov 20. J Biol Chem. 2009. PMID: 19028695 Free PMC article.
APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes.
Pardossi-Piquard R, Yang SP, Kanemoto S, Gu Y, Chen F, Böhm C, Sevalle J, Li T, Wong PC, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE. Pardossi-Piquard R, et al. Among authors: li t. J Biol Chem. 2009 Jun 12;284(24):16298-16307. doi: 10.1074/jbc.M109.000067. Epub 2009 Apr 15. J Biol Chem. 2009. PMID: 19369254 Free PMC article.
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