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COVID-19: towards understanding of pathogenesis.
Cao W, Li T. Cao W, et al. Cell Res. 2020 May;30(5):367-369. doi: 10.1038/s41422-020-0327-4. Cell Res. 2020. PMID: 32346073 Free PMC article. No abstract available.
Parallel decline of CD8+CD38+ lymphocytes and viremia in treated hepatitis B patients.
Cao W, Qiu ZF, Li TS. Cao W, et al. World J Gastroenterol. 2011 May 7;17(17):2191-8. doi: 10.3748/wjg.v17.i17.2191. World J Gastroenterol. 2011. PMID: 21633528 Free PMC article.
RESULTS: The peripheral CD4+ T cell counts and CD8+ T cell counts decreased in chronic HBV infection. In chronic hepatitis B patients, proportions of CD8+CD38+ T cells were 62.0% ± 14.7%, much higher than those of HBV carriers and healthy controls. ...CD8+ …
RESULTS: The peripheral CD4+ T cell counts and CD8+ T cell counts decreased in chronic HBV infection. In chronic hepatitis B p …
CD8+ T cell responses specific for hepatitis B virus core protein in patients with chronic hepatitis B virus infection.
Cao W, Qiu Z, Zhu T, Li Y, Han Y, Li T. Cao W, et al. J Clin Virol. 2014 Sep;61(1):40-6. doi: 10.1016/j.jcv.2014.06.022. Epub 2014 Jun 30. J Clin Virol. 2014. PMID: 25049205
CONCLUSIONS: Core-protein-specific T cell response plays an important role in chronic HBV infection. Inactive HBsAg carriers showed a much stronger core-protein-specific cytotoxic T cell response than other types of chronically infected patients. CD8+ CCR7-CD27+ …
CONCLUSIONS: Core-protein-specific T cell response plays an important role in chronic HBV infection. Inactive HBsAg carriers showed a …
[Clinical characteristics of 297 newly diagnosed Chinese HIV/AIDS patients].
Cao W, Song X, Li Y, Qiu Z, Xie J, Han Y, Lyu W, Wang H, Fan H, Zhou B, Liu Z, Liu X, Li T. Cao W, et al. Zhonghua Nei Ke Za Zhi. 2014 Jul;53(7):537-41. Zhonghua Nei Ke Za Zhi. 2014. PMID: 25264008 Chinese.
Median peripheral CD(+)4 T lymphocyte count in patients with ADC were 36 cells/µl. CONCLUSIONS: Common clinical presentations of HIV/AIDS included fever, weight loss, diarrhea, short of breath and mucocutaneous lesions. ...
Median peripheral CD(+)4 T lymphocyte count in patients with ADC were 36 cells/µl. CONCLUSIONS: Common clinical presentations of HIV/ …
CD4:CD8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed HIV-positive patients.
Lu W, Mehraj V, Vyboh K, Cao W, Li T, Routy JP. Lu W, et al. J Int AIDS Soc. 2015 Jun 29;18(1):20052. doi: 10.7448/IAS.18.1.20052. eCollection 2015. J Int AIDS Soc. 2015. PMID: 26130226 Free PMC article.
INTRODUCTION: Absolute CD4 T cell count and plasma viral load have been established as predictors of HIV disease progression, and CD4 T cell count is used as an indicator for initiation of antiretroviral therapy. Following long-term therapy, patients generally prese …
INTRODUCTION: Absolute CD4 T cell count and plasma viral load have been established as predictors of HIV disease progression, and CD4 …
Early Initiation Rather Than Prolonged Duration of Antiretroviral Therapy in HIV Infection Contributes to the Normalization of CD8 T-Cell Counts.
Cao W, Mehraj V, Trottier B, Baril JG, Leblanc R, Lebouche B, Cox J, Tremblay C, Lu W, Singer J, Li T, Routy JP; Montreal Primary HIV Infection Study Group, Vézina S, Charest L, Milne M, Huchet E, Lavoie S, Friedman J, Duchastel M, Villielm F, Côté P, Potter M, Lessard B, Charron MA, Dufresne S, Turgeon ME, Rouleau D, Labrecque L, Fortin C, de Pokomandy A, Hal-Gagné V, Munoz M, Deligne B, Martel-Laferrière V, Gilmore N, Fletcher M, Szabo J. Cao W, et al. Clin Infect Dis. 2016 Jan 15;62(2):250-257. doi: 10.1093/cid/civ809. Epub 2015 Sep 8. Clin Infect Dis. 2016. PMID: 26349551 Free PMC article.
BACKGROUND: CD8 T-cell counts remain elevated in human immunodeficiency virus (HIV) infection even after long-term antiretroviral therapy (ART), which is associated with an increased risk of non-AIDS-related events. ...More prominent CD4 T-cell recovery was observed …
BACKGROUND: CD8 T-cell counts remain elevated in human immunodeficiency virus (HIV) infection even after long-term antiretroviral the …
Aging of immune system: Immune signature from peripheral blood lymphocyte subsets in 1068 healthy adults.
Qin L, Jing X, Qiu Z, Cao W, Jiao Y, Routy JP, Li T. Qin L, et al. Aging (Albany NY). 2016 May;8(5):848-59. doi: 10.18632/aging.100894. Aging (Albany NY). 2016. PMID: 26886066 Free PMC article.
The decreased naïve CD4+ and CD8+ T cells, increased memory CD4+ or CD8+ T cells, loss of CD28 expression on T cells and reverse trend of CD38 and HLA-DR, were significant for aging of immune system. ...
The decreased naïve CD4+ and CD8+ T cells, increased memory CD4+ or CD8+ T cells, loss of CD28 expression on T cells an …
Elevation and persistence of CD8 T-cells in HIV infection: the Achilles heel in the ART era.
Cao W, Mehraj V, Kaufmann DE, Li T, Routy JP. Cao W, et al. J Int AIDS Soc. 2016 Mar 3;19(1):20697. doi: 10.7448/IAS.19.1.20697. eCollection 2016. J Int AIDS Soc. 2016. PMID: 26945343 Free PMC article. Review.
INTRODUCTION: HIV infection leads to a disturbed T-cell homeostasis, featured by a depletion of CD4 T-cells and a persistent elevation of CD8 T-cells over disease progression. ...Our search was focused on factors contributing to CD8 T-cell dynamics in …
INTRODUCTION: HIV infection leads to a disturbed T-cell homeostasis, featured by a depletion of CD4 T-cells and a persistent e …
[HIV antibody detection results in patients seeking medical care in Peking Union Medical College Hospital, 2003-2014].
Song XJ, Qiu ZF, Cao W, Xie J, Zhang ZJ, Xu SX, Li TS. Song XJ, et al. Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Jan 10;38(1):81-85. doi: 10.3760/cma.j.issn.0254-6450.2017.01.016. Zhonghua Liu Xing Bing Xue Za Zhi. 2017. PMID: 28100383 Chinese.
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