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Tumor cell death induced by topoisomerase-targeting drugs.
Li TK, Liu LF. Li TK, et al. Annu Rev Pharmacol Toxicol. 2001;41:53-77. doi: 10.1146/annurev.pharmtox.41.1.53. Annu Rev Pharmacol Toxicol. 2001. PMID: 11264450 Review.
2,3-Dimethoxybenzo[i]phenanthridines: topoisomerase I-targeting anticancer agents.
Li D, Zhao B, Sim SP, Li TK, Liu A, Liu LF, LaVoie EJ. Li D, et al. Bioorg Med Chem. 2003 Feb 20;11(4):521-8. doi: 10.1016/s0968-0896(02)00530-8. Bioorg Med Chem. 2003. PMID: 12538017
Substituted benzo[i]phenanthridines as mammalian topoisomerase-targeting agents.
Makhey D, Li D, Zhao B, Sim SP, Li TK, Liu A, Liu LF, LaVoie EJ. Makhey D, et al. Bioorg Med Chem. 2003 Apr 17;11(8):1809-20. doi: 10.1016/s0968-0896(03)00053-1. Bioorg Med Chem. 2003. PMID: 12659767
Acidic pH induces topoisomerase II-mediated DNA damage.
Xiao H, Li TK, Yang JM, Liu LF. Xiao H, et al. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5205-10. doi: 10.1073/pnas.0935978100. Epub 2003 Apr 11. Proc Natl Acad Sci U S A. 2003. PMID: 12692309 Free PMC article.
Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity.
Ruchelman AL, Kerrigan JE, Li TK, Zhou N, Liu A, Liu LF, LaVoie EJ. Ruchelman AL, et al. Bioorg Med Chem. 2004 Jul 1;12(13):3731-42. doi: 10.1016/j.bmc.2004.03.076. Bioorg Med Chem. 2004. PMID: 15186859
Hydrogen peroxide induces topoisomerase I-mediated DNA damage and cell death.
Daroui P, Desai SD, Li TK, Liu AA, Liu LF. Daroui P, et al. J Biol Chem. 2004 Apr 9;279(15):14587-94. doi: 10.1074/jbc.M311370200. Epub 2003 Dec 19. J Biol Chem. 2004. PMID: 14688260
Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.
Li TK, Houghton PJ, Desai SD, Daroui P, Liu AA, Hars ES, Ruchelman AL, LaVoie EJ, Liu LF. Li TK, et al. Cancer Res. 2003 Dec 1;63(23):8400-7. Cancer Res. 2003. PMID: 14679002
DNA damage-mediated apoptosis induced by selenium compounds.
Zhou N, Xiao H, Li TK, Nur-E-Kamal A, Liu LF. Zhou N, et al. J Biol Chem. 2003 Aug 8;278(32):29532-7. doi: 10.1074/jbc.M301877200. Epub 2003 May 24. J Biol Chem. 2003. PMID: 12766154
Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity.
Singh SK, Ruchelman AL, Li TK, Liu A, Liu LF, LaVoie EJ. Singh SK, et al. J Med Chem. 2003 May 22;46(11):2254-7. doi: 10.1021/jm020498a. J Med Chem. 2003. PMID: 12747798
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