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The kinase TNIK is an essential activator of Wnt target genes.
Mahmoudi T, Li VS, Ng SS, Taouatas N, Vries RG, Mohammed S, Heck AJ, Clevers H. Mahmoudi T, et al. Among authors: li vs. EMBO J. 2009 Nov 4;28(21):3329-40. doi: 10.1038/emboj.2009.285. Epub 2009 Oct 8. EMBO J. 2009. PMID: 19816403 Free PMC article.
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H. de Lau W, et al. Among authors: li vs. Nature. 2011 Jul 4;476(7360):293-7. doi: 10.1038/nature10337. Nature. 2011. PMID: 21727895
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.
Huch M, Bonfanti P, Boj SF, Sato T, Loomans CJ, van de Wetering M, Sojoodi M, Li VS, Schuijers J, Gracanin A, Ringnalda F, Begthel H, Hamer K, Mulder J, van Es JH, de Koning E, Vries RG, Heimberg H, Clevers H. Huch M, et al. Among authors: li vs. EMBO J. 2013 Oct 16;32(20):2708-21. doi: 10.1038/emboj.2013.204. Epub 2013 Sep 17. EMBO J. 2013. PMID: 24045232 Free PMC article.
Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.
Sasaki N, Sachs N, Wiebrands K, Ellenbroek SI, Fumagalli A, Lyubimova A, Begthel H, van den Born M, van Es JH, Karthaus WR, Li VS, López-Iglesias C, Peters PJ, van Rheenen J, van Oudenaarden A, Clevers H. Sasaki N, et al. Among authors: li vs. Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5399-407. doi: 10.1073/pnas.1607327113. Epub 2016 Aug 29. Proc Natl Acad Sci U S A. 2016. PMID: 27573849 Free PMC article.
85 results