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Emerging senolytic agents derived from natural products.
Li W, Qin L, Feng R, Hu G, Sun H, He Y, Zhang R. Li W, et al. Mech Ageing Dev. 2019 Jul;181:1-6. doi: 10.1016/j.mad.2019.05.001. Epub 2019 May 8. Mech Ageing Dev. 2019. PMID: 31077707 Review.
The curcumin analog EF24 is a novel senolytic agent.
Li W, He Y, Zhang R, Zheng G, Zhou D. Li W, et al. Aging (Albany NY). 2019 Jan 28;11(2):771-782. doi: 10.18632/aging.101787. Aging (Albany NY). 2019. PMID: 30694217 Free PMC article.
Bioactivities of EF24, a Novel Curcumin Analog: A Review.
He Y, Li W, Hu G, Sun H, Kong Q. He Y, et al. Among authors: li w. Front Oncol. 2018 Dec 11;8:614. doi: 10.3389/fonc.2018.00614. eCollection 2018. Front Oncol. 2018. PMID: 30619754 Free PMC article. Review.
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity.
He Y, Zhang X, Chang J, Kim HN, Zhang P, Wang Y, Khan S, Liu X, Zhang X, Lv D, Song L, Li W, Thummuri D, Yuan Y, Wiegand JS, Ortiz YT, Budamagunta V, Elisseeff JH, Campisi J, Almeida M, Zheng G, Zhou D. He Y, et al. Among authors: li w. Nat Commun. 2020 Apr 24;11(1):1996. doi: 10.1038/s41467-020-15838-0. Nat Commun. 2020. PMID: 32332723 Free PMC article.
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