Li Y - Search Results

1

Characterization of an RNA-cleaving deoxyribozyme with optimal activity at pH 5.

Kandadai SA, Mok WW, Ali MM, Li Y. Kandadai SA, et al. Among authors: li y. Biochemistry. 2009 Aug 11;48(31):7383-91. doi: 10.1021/bi900631u. Biochemistry. 2009. PMID: 19583262

An in vitro selection endeavor previously executed by our laboratory led to the isolation of a set of RNA-cleaving deoxyribozymes that thrive under acidic conditions [Liu, Z., Mei, S. H., Brennan, J. D., and Li, Y. (2003) J. Am. Chem. Soc. 125, 7539-7545]. One of th …

An in vitro selection endeavor previously executed by our laboratory led to the isolation of a set of RNA-cleaving deoxyribozymes that thriv …

2

Sequence diversity, metal specificity, and catalytic proficiency of metal-dependent phosphorylating DNA enzymes.

Wang W, Billen LP, Li Y. Wang W, et al. Among authors: li y. Chem Biol. 2002 Apr;9(4):507-17. doi: 10.1016/s1074-5521(02)00127-8. Chem Biol. 2002. PMID: 11983339

3

An efficient RNA-cleaving DNA enzyme that synchronizes catalysis with fluorescence signaling.

Mei SH, Liu Z, Brennan JD, Li Y. Mei SH, et al. Among authors: li y. J Am Chem Soc. 2003 Jan 15;125(2):412-20. doi: 10.1021/ja0281232. J Am Chem Soc. 2003. PMID: 12517153

4

Assemblage of signaling DNA enzymes with intriguing metal-ion specificities and pH dependences.

Liu Z, Mei SH, Brennan JD, Li Y. Liu Z, et al. Among authors: li y. J Am Chem Soc. 2003 Jun 25;125(25):7539-45. doi: 10.1021/ja035208+. J Am Chem Soc. 2003. PMID: 12812493

5

Dinucleotide junction cleavage versatility of 8-17 deoxyribozyme.

Cruz RP, Withers JB, Li Y. Cruz RP, et al. Among authors: li y. Chem Biol. 2004 Jan;11(1):57-67. doi: 10.1016/j.chembiol.2003.12.012. Chem Biol. 2004. PMID: 15112995 Free article.

6

Tracing sequence diversity change of RNA-cleaving deoxyribozymes under increasing selection pressure during in vitro selection.

Schlosser K, Li Y. Schlosser K, et al. Among authors: li y. Biochemistry. 2004 Aug 3;43(30):9695-707. doi: 10.1021/bi049757j. Biochemistry. 2004. PMID: 15274624

7

Secondary-structure characterization of two proficient kinase deoxyribozymes.

Achenbach JC, Jeffries GA, McManus SA, Billen LP, Li Y. Achenbach JC, et al. Among authors: li y. Biochemistry. 2005 Mar 15;44(10):3765-74. doi: 10.1021/bi0483054. Biochemistry. 2005. PMID: 15751953

8

Diverse evolutionary trajectories characterize a community of RNA-cleaving deoxyribozymes: a case study into the population dynamics of in vitro selection.

Schlosser K, Li Y. Schlosser K, et al. Among authors: li y. J Mol Evol. 2005 Aug;61(2):192-206. doi: 10.1007/s00239-004-0346-7. Epub 2005 Jun 27. J Mol Evol. 2005. PMID: 16007486

9

Characterizing the secondary structure and identifying functionally essential nucleotides of pH6DZ1, a fluorescence-signaling and RNA-cleaving deoxyribozyme.

Shen Y, Brennan JD, Li Y. Shen Y, et al. Among authors: li y. Biochemistry. 2005 Sep 13;44(36):12066-76. doi: 10.1021/bi050746f. Biochemistry. 2005. PMID: 16142904

10

Characterization of a catalytically efficient acidic RNA-cleaving deoxyribozyme.

Kandadai SA, Li Y. Kandadai SA, et al. Among authors: li y. Nucleic Acids Res. 2006 Jan 3;33(22):7164-75. doi: 10.1093/nar/gki1013. Print 2005. Nucleic Acids Res. 2006. PMID: 16391005 Free PMC article.

We previously demonstrated--through the isolation of RNA-cleaving deoxyribozymes by in vitro selection that are catalytically active in highly acidic solutions--that DNA, despite its chemical simplicity, could perform catalysis under challenging chemical conditions [Liu,Z., Mei,S …

We previously demonstrated--through the isolation of RNA-cleaving deoxyribozymes by in vitro selection that are catalytically active in high …

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