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Combining Tumor-Selective Bacterial Therapy with Salmonella typhimurium A1-R and Cancer Metabolism Targeting with Oral Recombinant Methioninase Regressed an Ewing's Sarcoma in a Patient-Derived Orthotopic Xenograft Model.
Miyake K, Kiyuna T, Li S, Han Q, Tan Y, Zhao M, Oshiro H, Kawaguchi K, Higuchi T, Zhang Z, Razmjooei S, Barangi M, Wangsiricharoen S, Murakami T, Singh AS, Li Y, Nelson SD, Eilber FC, Bouvet M, Hiroshima Y, Chishima T, Matsuyama R, Singh SR, Endo I, Hoffman RM. Miyake K, et al. Among authors: li s, li y. Chemotherapy. 2018;63(5):278-283. doi: 10.1159/000495574. Epub 2019 Jan 23. Chemotherapy. 2018. PMID: 30673664
High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model.
Kiyuna T, Murakami T, Tome Y, Kawaguchi K, Igarashi K, Zhang Y, Zhao M, Li Y, Bouvet M, Kanaya F, Singh A, Dry S, Eilber FC, Hoffman RM. Kiyuna T, et al. Among authors: li y. Oncotarget. 2016 May 31;7(22):33046-54. doi: 10.18632/oncotarget.8848. Oncotarget. 2016. PMID: 27105519 Free PMC article.
Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model.
Murakami T, Singh AS, Kiyuna T, Dry SM, Li Y, James AW, Igarashi K, Kawaguchi K, DeLong JC, Zhang Y, Hiroshima Y, Russell T, Eckardt MA, Yanagawa J, Federman N, Matsuyama R, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM. Murakami T, et al. Among authors: li y. Oncotarget. 2016 Jul 26;7(30):47556-47564. doi: 10.18632/oncotarget.9879. Oncotarget. 2016. PMID: 27286459 Free PMC article.
Vemurafenib-resistant BRAF-V600E-mutated melanoma is regressed by MEK-targeting drug trametinib, but not cobimetinib in a patient-derived orthotopic xenograft (PDOX) mouse model.
Kawaguchi K, Murakami T, Chmielowski B, Igarashi K, Kiyuna T, Unno M, Nelson SD, Russell TA, Dry SM, Li Y, Eilber FC, Hoffman RM. Kawaguchi K, et al. Among authors: li y. Oncotarget. 2016 Nov 1;7(44):71737-71743. doi: 10.18632/oncotarget.12328. Oncotarget. 2016. PMID: 27690220 Free PMC article.
Patient-derived orthotopic xenograft (PDOX) mouse model of adult rhabdomyosarcoma invades and recurs after resection in contrast to the subcutaneous ectopic model.
Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh A, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM. Igarashi K, et al. Among authors: li y. Cell Cycle. 2017 Jan 2;16(1):91-94. doi: 10.1080/15384101.2016.1252885. Epub 2016 Nov 10. Cell Cycle. 2017. PMID: 27830986 Free PMC article.
Tumor-targeting Salmonella typhimurium A1-R combined with temozolomide regresses malignant melanoma with a BRAF-V600E mutation in a patient-derived orthotopic xenograft (PDOX) model.
Kawaguchi K, Igarashi K, Murakami T, Chmielowski B, Kiyuna T, Zhao M, Zhang Y, Singh A, Unno M, Nelson SD, Russell TA, Dry SM, Li Y, Eilber FC, Hoffman RM. Kawaguchi K, et al. Among authors: li y. Oncotarget. 2016 Dec 27;7(52):85929-85936. doi: 10.18632/oncotarget.13231. Oncotarget. 2016. PMID: 27835903 Free PMC article.
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