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A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells.
Lee JS, Heo J, Libbrecht L, Chu IS, Kaposi-Novak P, Calvisi DF, Mikaelyan A, Roberts LR, Demetris AJ, Sun Z, Nevens F, Roskams T, Thorgeirsson SS. Lee JS, et al. Nat Med. 2006 Apr;12(4):410-6. doi: 10.1038/nm1377. Epub 2006 Mar 12. Nat Med. 2006. PMID: 16532004
Time-dependent effect of hypoxia on tumor progression and liver progenitor cell markers in primary liver tumors.
Bogaerts E, Heindryckx F, Devisscher L, Paridaens A, Vandewynckel YP, Van den Bussche A, Verhelst X, Libbrecht L, van Grunsven LA, Geerts A, Van Vlierberghe H. Bogaerts E, et al. PLoS One. 2015 Mar 20;10(3):e0119555. doi: 10.1371/journal.pone.0119555. eCollection 2015. PLoS One. 2015. PMID: 25793288 Free PMC article.
Expression of multidrug resistance-associated protein 1 in hepatocellular carcinoma is associated with a more aggressive tumour phenotype and may reflect a progenitor cell origin.
Vander Borght S, Komuta M, Libbrecht L, Katoonizadeh A, Aerts R, Dymarkowski S, Verslype C, Nevens F, Roskams T. Vander Borght S, et al. Liver Int. 2008 Dec;28(10):1370-80. doi: 10.1111/j.1478-3231.2008.01889.x. Liver Int. 2008. PMID: 19055643
Progenitor cells in diseased human liver.
Roskams TA, Libbrecht L, Desmet VJ. Roskams TA, et al. Semin Liver Dis. 2003 Nov;23(4):385-96. doi: 10.1055/s-2004-815564. Semin Liver Dis. 2003. PMID: 14722815 Review.
Hepatic progenitor cells in human liver tumor development.
Libbrecht L. Libbrecht L. World J Gastroenterol. 2006 Oct 21;12(39):6261-5. doi: 10.3748/wjg.v12.i39.6261. World J Gastroenterol. 2006. PMID: 17072946 Free PMC article. Review.
Central role of c-Myc during malignant conversion in human hepatocarcinogenesis.
Kaposi-Novak P, Libbrecht L, Woo HG, Lee YH, Sears NC, Coulouarn C, Conner EA, Factor VM, Roskams T, Thorgeirsson SS. Kaposi-Novak P, et al. Cancer Res. 2009 Apr 1;69(7):2775-82. doi: 10.1158/0008-5472.CAN-08-3357. Epub 2009 Mar 10. Cancer Res. 2009. PMID: 19276364 Free PMC article.
A seven-gene set associated with chronic hypoxia of prognostic importance in hepatocellular carcinoma.
van Malenstein H, Gevaert O, Libbrecht L, Daemen A, Allemeersch J, Nevens F, Van Cutsem E, Cassiman D, De Moor B, Verslype C, van Pelt J. van Malenstein H, et al. Clin Cancer Res. 2010 Aug 15;16(16):4278-88. doi: 10.1158/1078-0432.CCR-09-3274. Epub 2010 Jun 30. Clin Cancer Res. 2010. PMID: 20592013
Hepatic progenitor cells in human liver diseases.
Libbrecht L, Roskams T. Libbrecht L, et al. Semin Cell Dev Biol. 2002 Dec;13(6):389-96. doi: 10.1016/s1084952102001258. Semin Cell Dev Biol. 2002. PMID: 12468238 Review.
Hepatic progenitor cells in hepatocellular adenomas.
Libbrecht L, De Vos R, Cassiman D, Desmet V, Aerts R, Roskams T. Libbrecht L, et al. Am J Surg Pathol. 2001 Nov;25(11):1388-96. doi: 10.1097/00000478-200111000-00006. Am J Surg Pathol. 2001. PMID: 11684955
The clinicopathological and prognostic relevance of cytokeratin 7 and 19 expression in hepatocellular carcinoma. A possible progenitor cell origin.
Durnez A, Verslype C, Nevens F, Fevery J, Aerts R, Pirenne J, Lesaffre E, Libbrecht L, Desmet V, Roskams T. Durnez A, et al. Histopathology. 2006 Aug;49(2):138-51. doi: 10.1111/j.1365-2559.2006.02468.x. Histopathology. 2006. PMID: 16879391
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