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4'-Fluorouridine is a broad-spectrum orally efficacious antiviral blocking respiratory syncytial virus and SARS-CoV-2 replication.
Sourimant J, Lieber CM, Aggarwal M, Cox RM, Wolf JD, Yoon JJ, Toots M, Ye C, Sticher Z, Kolykhalov AA, Martinez-Sobrido L, Bluemling GR, Natchus MG, Painter GR, Plemper RK. Sourimant J, et al. Among authors: lieber cm. bioRxiv [Preprint]. 2021 May 20:2021.05.19.444875. doi: 10.1101/2021.05.19.444875. bioRxiv. 2021. Update in: Science. 2022 Jan 14;375(6577):161-167. doi: 10.1126/science.abj5508. PMID: 34031658 Free PMC article. Updated. Preprint.
SARS-CoV-2 variant of concern type and biological sex affect efficacy of molnupiravir in dwarf hamster model of severe COVID-19.
Lieber CM, Cox RM, Sourimant J, Wolf JD, Juergens K, Phung Q, Saindane MT, Natchus MG, Painter GR, Sakamoto K, Greninger AL, Plemper RK. Lieber CM, et al. bioRxiv [Preprint]. 2022 Feb 7:2022.02.04.479171. doi: 10.1101/2022.02.04.479171. bioRxiv. 2022. Update in: Nat Commun. 2022 Jul 29;13(1):4416. doi: 10.1038/s41467-022-32045-1. PMID: 35169793 Free PMC article. Updated. Preprint.
Paxlovid-like nirmatrelvir/ritonavir fails to block SARS-CoV-2 transmission in ferrets.
Cox RM, Lieber CM, Wolf JD, Karimi A, Lieberman NAP, Sticher ZM, Roychoudhury P, Andrews MK, Krueger RE, Natchus MG, Painter GR, Kolykhalov AA, Greninger AL, Plemper RK. Cox RM, et al. Among authors: lieber cm. bioRxiv [Preprint]. 2022 Nov 21:2022.11.20.517271. doi: 10.1101/2022.11.20.517271. bioRxiv. 2022. PMID: 36451893 Free PMC article. Preprint.
Influenza A virus resistance to 4'-fluorouridine coincides with viral attenuation in vitro and in vivo.
Lieber CM, Kang HJ, Aggarwal M, Lieberman NA, Sobolik EB, Yoon JJ, Natchus MG, Cox RM, Greninger AL, Plemper RK. Lieber CM, et al. bioRxiv [Preprint]. 2023 Oct 21:2023.10.20.563370. doi: 10.1101/2023.10.20.563370. bioRxiv. 2023. Update in: PLoS Pathog. 2024 Feb 1;20(2):e1011993. doi: 10.1371/journal.ppat.1011993. PMID: 37905070 Free PMC article. Updated. Preprint.
Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets.
Cox RM, Wolf JD, Lieberman NA, Lieber CM, Kang HJ, Sticher ZM, Yoon JJ, Andrews MK, Govindarajan M, Krueger RE, Sobolik EB, Natchus MG, Gewirtz AT, deSwart RL, Kolykhalov AA, Hekmatyar K, Sakamoto K, Greninger AL, Plemper RK. Cox RM, et al. Among authors: lieber cm. Nat Commun. 2024 Feb 8;15(1):1189. doi: 10.1038/s41467-024-45418-5. Nat Commun. 2024. PMID: 38331906 Free PMC article.
The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo.
Rhodin MHJ, Reyes AC, Balakrishnan A, Bisht N, Kelly NM, Gibbons JS, Lloyd J, Vaine M, Cressey T, Crepeau M, Shen R, Manalo N, Castillo J, Levene RE, Leonard D, Zang T, Jiang L, Daniels K, Cox RM, Lieber CM, Wolf JD, Plemper RK, Leist SR, Scobey T, Baric RS, Wang G, Goodwin B, Or YS. Rhodin MHJ, et al. Among authors: lieber cm. Nat Commun. 2024 Aug 1;15(1):6503. doi: 10.1038/s41467-024-50931-8. Nat Commun. 2024. PMID: 39090095 Free PMC article.
241 results