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Year Number of Results
2006 1
2007 1
2014 4
2015 2
2016 8
2017 5
2018 8
2019 4
2020 4
2021 9
2022 6
2023 12
2024 7
2025 4
2026 5

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73 results

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Page 1
EGFR activation limits the response of liver cancer to lenvatinib.
Jin H, Shi Y, Lv Y, Yuan S, Ramirez CFA, Lieftink C, Wang L, Wang S, Wang C, Dias MH, Jochems F, Yang Y, Bosma A, Hijmans EM, de Groot MHP, Vegna S, Cui D, Zhou Y, Ling J, Wang H, Guo Y, Zheng X, Isima N, Wu H, Sun C, Beijersbergen RL, Akkari L, Zhou W, Zhai B, Qin W, Bernards R. Jin H, et al. Among authors: lieftink c. Nature. 2021 Jul;595(7869):730-734. doi: 10.1038/s41586-021-03741-7. Epub 2021 Jul 21. Nature. 2021. PMID: 34290403
Inducing and exploiting vulnerabilities for the treatment of liver cancer.
Wang C, Vegna S, Jin H, Benedict B, Lieftink C, Ramirez C, de Oliveira RL, Morris B, Gadiot J, Wang W, du Chatinier A, Wang L, Gao D, Evers B, Jin G, Xue Z, Schepers A, Jochems F, Sanchez AM, Mainardi S, Te Riele H, Beijersbergen RL, Qin W, Akkari L, Bernards R. Wang C, et al. Among authors: lieftink c. Nature. 2019 Oct;574(7777):268-272. doi: 10.1038/s41586-019-1607-3. Epub 2019 Oct 2. Nature. 2019. PMID: 31578521 Free PMC article.
Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy.
Dias MH, Friskes A, Wang S, Fernandes Neto JM, van Gemert F, Mourragui S, Papagianni C, Kuiken HJ, Mainardi S, Alvarez-Villanueva D, Lieftink C, Morris B, Dekker A, van Dijk E, Wilms LHS, da Silva MS, Jansen RA, Mulero-Sánchez A, Malzer E, Vidal A, Santos C, Salazar R, Wailemann RAM, Torres TEP, De Conti G, Raaijmakers JA, Snaebjornsson P, Yuan S, Qin W, Kovach JS, Armelin HA, Te Riele H, van Oudenaarden A, Jin H, Beijersbergen RL, Villanueva A, Medema RH, Bernards R. Dias MH, et al. Among authors: lieftink c. Cancer Discov. 2024 Jul 1;14(7):1276-1301. doi: 10.1158/2159-8290.CD-23-0216. Cancer Discov. 2024. PMID: 38533987 Free PMC article.
cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis.
Wang L, Jin H, Jochems F, Wang S, Lieftink C, Martinez IM, De Conti G, Edwards F, de Oliveira RL, Schepers A, Zhou Y, Zheng J, Wu W, Zheng X, Yuan S, Ling J, Jastrzebski K, Santos Dias MD, Song JY, Celie PNH, Yagita H, Yao M, Zhou W, Beijersbergen RL, Qin W, Bernards R. Wang L, et al. Among authors: lieftink c. Nat Cancer. 2022 Nov;3(11):1284-1299. doi: 10.1038/s43018-022-00462-2. Epub 2022 Nov 22. Nat Cancer. 2022. PMID: 36414711
CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma.
Yang W, Wang S, Ji S, Wang J, Lian S, Li Z, Jansen RA, Wu W, Niu K, Sun Z, Jia Q, Zheng J, Zhu H, Deng X, Wang L, Fan Z, Shi Y, Lieftink C, Guan M, Beijersbergen RL, Qin W, Gao Q, Bernards R, Jin H. Yang W, et al. Among authors: lieftink c. Proc Natl Acad Sci U S A. 2025 Sep 30;122(39):e2519568122. doi: 10.1073/pnas.2519568122. Epub 2025 Sep 24. Proc Natl Acad Sci U S A. 2025. PMID: 40991439 Free PMC article.
Epigenetic profiling identifies markers of endocrine resistance and therapeutic options for metastatic castration-resistant prostate cancer.
Severson TM, Minnee E, Zhu Y, Schuurman K, Nguyen HM, Brown LG, Hakkola S, Menezes R, Gregoricchio S, Kim Y, Kneppers J, Linder S, Stelloo S, Lieftink C, van der Heijden MS, Nykter M, van der Noort V, Sanders J, Morris B, Jenster G, van Leenders GJ, Pomerantz M, Freedman ML, Beijersbergen RL, Urbanucci A, Wessels L, Nelson PS, Corey E, Prekovic S, Zwart W, Bergman AM. Severson TM, et al. Among authors: lieftink c. Cell Rep Med. 2025 Jul 15;6(7):102215. doi: 10.1016/j.xcrm.2025.102215. Epub 2025 Jul 2. Cell Rep Med. 2025. PMID: 40609538 Free PMC article. Clinical Trial.
An antibiotic that mediates immune destruction of senescent cancer cells.
Casagrande Raffi G, Chen J, Feng X, Chen Z, Lieftink C, Deng S, Mo J, Zeng C, Steur M, Wang J, Bleijerveld OB, Hoekman L, van der Wel N, Wang F, Beijersbergen R, Zheng J, Bernards R, Wang L. Casagrande Raffi G, et al. Among authors: lieftink c. Proc Natl Acad Sci U S A. 2024 Dec 24;121(52):e2417724121. doi: 10.1073/pnas.2417724121. Epub 2024 Dec 18. Proc Natl Acad Sci U S A. 2024. PMID: 39693343 Free PMC article.
PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair.
Andronikou C, Burdova K, Dibitetto D, Lieftink C, Malzer E, Kuiken HJ, Gogola E, Ray Chaudhuri A, Beijersbergen RL, Hanzlikova H, Jonkers J, Rottenberg S. Andronikou C, et al. Among authors: lieftink c. EMBO J. 2024 Mar;43(6):1015-1042. doi: 10.1038/s44318-024-00043-2. Epub 2024 Feb 15. EMBO J. 2024. PMID: 38360994 Free PMC article.
Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse.
Chen M, Mainardi S, Lieftink C, Velds A, de Rink I, Yang C, Kuiken HJ, Morris B, Edwards F, Jochems F, van Tellingen O, Boeije M, Proost N, Jansen RA, Qin S, Jin H, Koen van der Mijn JC, Schepers A, Venkatesan S, Qin W, Beijersbergen RL, Wang L, Bernards R. Chen M, et al. Among authors: lieftink c. Cell Rep Med. 2024 Mar 19;5(3):101471. doi: 10.1016/j.xcrm.2024.101471. Cell Rep Med. 2024. PMID: 38508142 Free PMC article.
ADARp150 counteracts whole genome duplication.
van Gemert F, Drakaki A, Lozano IM, de Groot D, Uiterkamp MS, Proost N, Lieftink C, van de Ven M, Beijersbergen RL, Jacobs H, Te Riele H. van Gemert F, et al. Among authors: lieftink c. Nucleic Acids Res. 2024 Sep 23;52(17):10370-10384. doi: 10.1093/nar/gkae700. Nucleic Acids Res. 2024. PMID: 39189458 Free PMC article.
73 results