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Large-Scale Production of LGR5-Positive Bipotential Human Liver Stem Cells.
Schneeberger K, Sánchez-Romero N, Ye S, van Steenbeek FG, Oosterhoff LA, Pla Palacin I, Chen C, van Wolferen ME, van Tienderen G, Lieshout R, Colemonts-Vroninks H, Schene I, Hoekstra R, Verstegen MMA, van der Laan LJW, Penning LC, Fuchs SA, Clevers H, De Kock J, Baptista PM, Spee B. Schneeberger K, et al. Among authors: lieshout r. Hepatology. 2020 Jul;72(1):257-270. doi: 10.1002/hep.31037. Epub 2020 Apr 8. Hepatology. 2020. PMID: 31715015 Free PMC article.
Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.
Broutier L, Mastrogiovanni G, Verstegen MM, Francies HE, Gavarró LM, Bradshaw CR, Allen GE, Arnes-Benito R, Sidorova O, Gaspersz MP, Georgakopoulos N, Koo BK, Dietmann S, Davies SE, Praseedom RK, Lieshout R, IJzermans JNM, Wigmore SJ, Saeb-Parsy K, Garnett MJ, van der Laan LJ, Huch M. Broutier L, et al. Among authors: lieshout r. Nat Med. 2017 Dec;23(12):1424-1435. doi: 10.1038/nm.4438. Epub 2017 Nov 13. Nat Med. 2017. PMID: 29131160 Free PMC article.
Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance.
Liu J, Li P, Wang L, Li M, Ge Z, Noordam L, Lieshout R, Verstegen MMA, Ma B, Su J, Yang Q, Zhang R, Zhou G, Carrascosa LC, Sprengers D, IJzermans JNM, Smits R, Kwekkeboom J, van der Laan LJW, Peppelenbosch MP, Pan Q, Cao W. Liu J, et al. Among authors: lieshout r. Cell Mol Gastroenterol Hepatol. 2021;11(2):407-431. doi: 10.1016/j.jcmgh.2020.09.003. Epub 2020 Sep 12. Cell Mol Gastroenterol Hepatol. 2021. PMID: 32932015 Free PMC article.
Precancerous liver diseases do not cause increased mutagenesis in liver stem cells.
Nguyen L, Jager M, Lieshout R, de Ruiter PE, Locati MD, Besselink N, van der Roest B, Janssen R, Boymans S, de Jonge J, IJzermans JNM, Doukas M, Verstegen MMA, van Boxtel R, van der Laan LJW, Cuppen E, Kuijk E. Nguyen L, et al. Among authors: lieshout r. Commun Biol. 2021 Nov 18;4(1):1301. doi: 10.1038/s42003-021-02839-y. Commun Biol. 2021. PMID: 34795391 Free PMC article.
Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells.
Zhou G, Lieshout R, van Tienderen GS, de Ruiter V, van Royen ME, Boor PPC, Magré L, Desai J, Köten K, Kan YY, Ge Z, Campos Carrascosa L, Geuijen C, Sprengers D, van der Laan LJW, Verstegen MMA, Kwekkeboom J. Zhou G, et al. Among authors: lieshout r. Br J Cancer. 2022 Sep;127(4):649-660. doi: 10.1038/s41416-022-01839-x. Epub 2022 May 21. Br J Cancer. 2022. PMID: 35597867 Free PMC article.
226 results