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Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.
Hadchouel J, Soukaseum C, Büsst C, Zhou XO, Baudrie V, Zürrer T, Cambillau M, Elghozi JL, Lifton RP, Loffing J, Jeunemaitre X. Hadchouel J, et al. Among authors: lifton rp. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18109-14. doi: 10.1073/pnas.1006128107. Epub 2010 Oct 4. Proc Natl Acad Sci U S A. 2010. PMID: 20921400 Free PMC article.
C-terminally truncated, kidney-specific variants of the WNK4 kinase lack several sites that regulate its activity.
Murillo-de-Ozores AR, Rodríguez-Gama A, Bazúa-Valenti S, Leyva-Ríos K, Vázquez N, Pacheco-Álvarez D, De La Rosa-Velázquez IA, Wengi A, Stone KL, Zhang J, Loffing J, Lifton RP, Yang CL, Ellison DH, Gamba G, Castañeda-Bueno M. Murillo-de-Ozores AR, et al. Among authors: lifton rp. J Biol Chem. 2018 Aug 3;293(31):12209-12221. doi: 10.1074/jbc.RA118.003037. Epub 2018 Jun 19. J Biol Chem. 2018. PMID: 29921588 Free PMC article.
Finding genes that cause human hypertension.
Lifton RP, Jeunemaitre X. Lifton RP, et al. J Hypertens. 1993 Mar;11(3):231-6. doi: 10.1097/00004872-199303000-00002. J Hypertens. 1993. PMID: 8387080 Review.
WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis.
Rinehart J, Kahle KT, de Los Heros P, Vazquez N, Meade P, Wilson FH, Hebert SC, Gimenez I, Gamba G, Lifton RP. Rinehart J, et al. Among authors: lifton rp. Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16777-82. doi: 10.1073/pnas.0508303102. Epub 2005 Nov 7. Proc Natl Acad Sci U S A. 2005. PMID: 16275913 Free PMC article.
Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.
Ponce-Coria J, San-Cristobal P, Kahle KT, Vazquez N, Pacheco-Alvarez D, de Los Heros P, Juárez P, Muñoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G. Ponce-Coria J, et al. Among authors: lifton rp. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8458-63. doi: 10.1073/pnas.0802966105. Epub 2008 Jun 11. Proc Natl Acad Sci U S A. 2008. PMID: 18550832 Free PMC article.
Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway.
San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G. San-Cristobal P, et al. Among authors: lifton rp. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4384-9. doi: 10.1073/pnas.0813238106. Epub 2009 Feb 24. Proc Natl Acad Sci U S A. 2009. PMID: 19240212 Free PMC article.
426 results