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Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK.
Murray PB, Lax I, Reshetnyak A, Ligon GF, Lillquist JS, Natoli EJ Jr, Shi X, Folta-Stogniew E, Gunel M, Alvarado D, Schlessinger J. Murray PB, et al. Among authors: ligon gf. Sci Signal. 2015 Jan 20;8(360):ra6. doi: 10.1126/scisignal.2005916. Sci Signal. 2015. PMID: 25605972