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Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.
Bleasdale JE, Ogg D, Palazuk BJ, Jacob CS, Swanson ML, Wang XY, Thompson DP, Conradi RA, Mathews WR, Laborde AL, Stuchly CW, Heijbel A, Bergdahl K, Bannow CA, Smith CW, Svensson C, Liljebris C, Schostarez HJ, May PD, Stevens FC, Larsen SD. Bleasdale JE, et al. Among authors: liljebris c. Biochemistry. 2001 May 15;40(19):5642-54. doi: 10.1021/bi002865v. Biochemistry. 2001. PMID: 11341829
Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia, but XS004, a novel oral dasatinib formulation, provides reduced pH-dependence, minimizing undesirable drug-drug interactions.
Larfors G, Andersson P, Jesson G, Liljebris C, Brisander M, Lennernäs H, Stenke L. Larfors G, et al. Among authors: liljebris c. Eur J Haematol. 2023 Oct;111(4):644-654. doi: 10.1111/ejh.14059. Epub 2023 Jul 28. Eur J Haematol. 2023. PMID: 37503797