Lim SM - Search Results

1

Identification of β-Lapachone Analogs as Novel MALT1 Inhibitors To Treat an Aggressive Subtype of Diffuse Large B-Cell Lymphoma.

Lim SM, Jeong Y, Lee S, Im H, Tae HS, Kim BG, Park HD, Park J, Hong S. Lim SM, et al. J Med Chem. 2015 Nov 12;58(21):8491-502. doi: 10.1021/acs.jmedchem.5b01415. Epub 2015 Oct 29. J Med Chem. 2015. PMID: 26496175

2

Pharmacological targeting of the pseudokinase Her3.

Xie T, Lim SM, Westover KD, Dodge ME, Ercan D, Ficarro SB, Udayakumar D, Gurbani D, Tae HS, Riddle SM, Sim T, Marto JA, Jänne PA, Crews CM, Gray NS. Xie T, et al. Among authors: lim sm. Nat Chem Biol. 2014 Dec;10(12):1006-12. doi: 10.1038/nchembio.1658. Epub 2014 Oct 19. Nat Chem Biol. 2014. PMID: 25326665 Free PMC article.

3

Development of small molecules targeting the pseudokinase Her3.

Lim SM, Xie T, Westover KD, Ficarro SB, Tae HS, Gurbani D, Sim T, Marto JA, Jänne PA, Crews CM, Gray NS. Lim SM, et al. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3382-9. doi: 10.1016/j.bmcl.2015.04.103. Epub 2015 May 11. Bioorg Med Chem Lett. 2015. PMID: 26094118 Free PMC article.

4

Discovery of wrightiadione as a novel template for the TrkA kinase inhibitors.

Jeong Y, Lim SM, Hong S. Jeong Y, et al. Among authors: lim sm. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5186-9. doi: 10.1016/j.bmcl.2015.09.070. Epub 2015 Sep 30. Bioorg Med Chem Lett. 2015. PMID: 26442778

5

Strategies to overcome acquired resistances conferred by mutations in the kinase domain of EGFR.

Lim SM, Jeong Y, Hong S. Lim SM, et al. Future Med Chem. 2016 May;8(8):853-78. doi: 10.4155/fmc-2016-0019. Epub 2016 May 19. Future Med Chem. 2016. PMID: 27195594 Review.

6

Optimization and biological evaluation of aminopyrimidine-based IκB kinase β inhibitors with potent anti-inflammatory effects.

Shin Y, Lim SM, Yan HH, Jung S, Fang Z, Jung KH, Hong SS, Hong S. Shin Y, et al. Among authors: lim sm. Eur J Med Chem. 2016 Nov 10;123:544-556. doi: 10.1016/j.ejmech.2016.07.075. Epub 2016 Aug 1. Eur J Med Chem. 2016. PMID: 27517803

7

Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity.

Kim T, Son WS, Morshed MN, Londhe AM, Jung SY, Park JH, Park WK, Lim SM, Park KD, Cho SJ, Jeong KS, Lee J, Pae AN. Kim T, et al. Among authors: lim sm. Eur J Med Chem. 2017 Dec 1;141:240-256. doi: 10.1016/j.ejmech.2017.09.033. Epub 2017 Sep 21. Eur J Med Chem. 2017. PMID: 29031071

8

Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease.

Lim JW, Kim SK, Choi SY, Kim DH, Gadhe CG, Lee HN, Kim HJ, Kim J, Cho SJ, Hwang H, Seong J, Jeong KS, Lee JY, Lim SM, Lee JW, Pae AN. Lim JW, et al. Among authors: lim sm. Eur J Med Chem. 2018 Sep 5;157:405-422. doi: 10.1016/j.ejmech.2018.07.071. Epub 2018 Aug 3. Eur J Med Chem. 2018. PMID: 30103190

9

Broad spectrum alkynyl inhibitors of T315I Bcr-Abl.

Deng X, Lim SM, Zhang J, Gray NS. Deng X, et al. Among authors: lim sm. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4196-200. doi: 10.1016/j.bmcl.2010.05.043. Epub 2010 May 19. Bioorg Med Chem Lett. 2010. PMID: 20541934 Free PMC article.

10

Covalent Guanosine Mimetic Inhibitors of G12C KRAS.

Xiong Y, Lu J, Hunter J, Li L, Scott D, Choi HG, Lim SM, Manandhar A, Gondi S, Sim T, Westover KD, Gray NS. Xiong Y, et al. Among authors: lim sm. ACS Med Chem Lett. 2016 Nov 30;8(1):61-66. doi: 10.1021/acsmedchemlett.6b00373. eCollection 2017 Jan 12. ACS Med Chem Lett. 2016. PMID: 28105276 Free PMC article.

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