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Limited immunogenicity of HIV CD8+ T-cell epitopes in acute Clade C virus infection.
Radebe M, Nair K, Chonco F, Bishop K, Wright JK, van der Stok M, Bassett IV, Mncube Z, Altfeld M, Walker BD, Ndung'u T. Radebe M, et al. J Infect Dis. 2011 Sep 1;204(5):768-76. doi: 10.1093/infdis/jir394. J Infect Dis. 2011. PMID: 21844303 Free PMC article.
BACKGROUND: Human immunodeficiency virus type 1 (HIV-1)-specific CD8(+) responses contribute to the decline in acute peak viremia following infection. However, data on the relative immunogenicity of CD8(+) T-cell epitopes
BACKGROUND: Human immunodeficiency virus type 1 (HIV-1)-specific CD8(+) responses contribute to the decline in acute pe …
Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution.
Allen TM, Altfeld M, Geer SC, Kalife ET, Moore C, O'sullivan KM, Desouza I, Feeney ME, Eldridge RL, Maier EL, Kaufmann DE, Lahaie MP, Reyor L, Tanzi G, Johnston MN, Brander C, Draenert R, Rockstroh JK, Jessen H, Rosenberg ES, Mallal SA, Walker BD. Allen TM, et al. J Virol. 2005 Nov;79(21):13239-49. doi: 10.1128/JVI.79.21.13239-13249.2005. J Virol. 2005. PMID: 16227247 Free PMC article.
To address this issue we assessed the relationship between genome-wide viral evolution and adaptive CD8+ T-cell responses in four clade B virus-infected patients studied longitudinally for as long as 5 years after acute infection. …
To address this issue we assessed the relationship between genome-wide viral evolution and adaptive CD8+ T-cell respons …
High frequency of transmitted HIV-1 Gag HLA class I-driven immune escape variants but minimal immune selection over the first year of clade C infection.
Gounder K, Padayachi N, Mann JK, Radebe M, Mokgoro M, van der Stok M, Mkhize L, Mncube Z, Jaggernath M, Reddy T, Walker BD, Ndung'u T. Gounder K, et al. PLoS One. 2015 Mar 17;10(3):e0119886. doi: 10.1371/journal.pone.0119886. eCollection 2015. PLoS One. 2015. PMID: 25781986 Free PMC article.
In chronic HIV infection, CD8+ T cell responses to Gag are associated with lower viral loads, but longitudinal studies of HLA-restricted CD8+ T cell-driven selection pressure in Gag from the time of acute infection
In chronic HIV infection, CD8+ T cell responses to Gag are associated with lower viral loads, but longitu …