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Activation of the JNK signaling pathway: breaking the brake on apoptosis.
Lin A. Lin A. Bioessays. 2003 Jan;25(1):17-24. doi: 10.1002/bies.10204. Bioessays. 2003. PMID: 12508278 Review.
The role of JNK activation in apoptosis is highly controversial, being suggested to have a pro-apoptotic, anti-apoptotic or no role in this process. It appears that the JNK pathway functions in a cell-type and stimulus-dependent manner and its different components c …
The role of JNK activation in apoptosis is highly controversial, being suggested to have a pro-apoptotic, anti-apoptotic or no role i …
Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15.
Tang F, Chen Z, Ciszewski C, Setty M, Solus J, Tretiakova M, Ebert E, Han J, Lin A, Guandalini S, Groh V, Spies T, Green P, Jabri B. Tang F, et al. Among authors: lin a. J Exp Med. 2009 Mar 16;206(3):707-19. doi: 10.1084/jem.20071887. Epub 2009 Feb 23. J Exp Med. 2009. PMID: 19237603 Free PMC article.
Here, we identify cytosolic phospholipase A(2) (cPLA(2)) as a central molecule in NKG2D-mediated cytolysis in CTLs. Furthermore, we report that NKG2D induces, upon recognition of MIC(+) target cells, the release of arachidonic acid (AA) by CTLs to promote tissue inf …
Here, we identify cytosolic phospholipase A(2) (cPLA(2)) as a central molecule in NKG2D-mediated cytolysis in CTLs. Furthermor …
Integration of apoptosis signal-regulating kinase 1-mediated stress signaling with the Akt/protein kinase B-IκB kinase cascade.
Puckett MC, Goldman EH, Cockrell LM, Huang B, Kasinski AL, Du Y, Wang CY, Lin A, Ichijo H, Khuri F, Fu H. Puckett MC, et al. Among authors: lin a. Mol Cell Biol. 2013 Jun;33(11):2252-9. doi: 10.1128/MCB.00047-13. Epub 2013 Mar 25. Mol Cell Biol. 2013. PMID: 23530055 Free PMC article.
IKK forms a complex with and phosphorylates ASK1 at a sensor site, Ser967, leading to the recruitment of 14-3-3, counteracts stress signal-triggered ASK1 activation, and suppresses ASK1-mediated functions. ...Our data suggest that IKK has a dual role: a
IKK forms a complex with and phosphorylates ASK1 at a sensor site, Ser967, leading to the recruitment of 14-3-3, counteracts s …
Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia.
Chen M, Yan R, Zhou K, Li X, Zhang Y, Liu C, Jiang M, Ye H, Meng X, Pang N, Zhao L, Liu J, Xiao W, Hu R, Cui Q, Zhong W, Zhao Y, Zhu M, Lin A, Ruan C, Dai K. Chen M, et al. Among authors: lin a. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10682-E10691. doi: 10.1073/pnas.1808217115. Epub 2018 Oct 18. Proc Natl Acad Sci U S A. 2018. PMID: 30337485 Free PMC article.
Androgen and its receptor promote Bax-mediated apoptosis.
Lin Y, Kokontis J, Tang F, Godfrey B, Liao S, Lin A, Chen Y, Xiang J. Lin Y, et al. Among authors: lin a. Mol Cell Biol. 2006 Mar;26(5):1908-16. doi: 10.1128/MCB.26.5.1908-1916.2006. Mol Cell Biol. 2006. PMID: 16479009 Free PMC article.
Thus, our results reveal a novel cross talk between the androgen/AR hormonal signaling pathway and the intrinsic apoptotic death pathway that determines the sensitivity of stress-induced apoptosis in prostate cancer cells....
Thus, our results reveal a novel cross talk between the androgen/AR hormonal signaling pathway and the intrinsic apoptotic death path …
NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta.
Liu J, Yang D, Minemoto Y, Leitges M, Rosner MR, Lin A. Liu J, et al. Among authors: lin a. Mol Cell. 2006 Feb 17;21(4):467-80. doi: 10.1016/j.molcel.2005.12.020. Mol Cell. 2006. PMID: 16483929
Thus, our results demonstrate that RelA/NF-kappaB via PKCdelta positively regulates UV-induced JNK activation and provide a mechanism by which NF-kappaB promotes UV-induced apoptosis....
Thus, our results demonstrate that RelA/NF-kappaB via PKCdelta positively regulates UV-induced JNK activation and provide a mechanism …
ATIA: a link between inflammation and hypoxia.
Lin A. Lin A. Mol Cell. 2011 Jun 10;42(5):557-8. doi: 10.1016/j.molcel.2011.05.023. Mol Cell. 2011. PMID: 21658597 Free PMC article.
Temporal control of TNFα signaling by Miz1.
Lin A. Lin A. Adv Exp Med Biol. 2011;691:127-8. doi: 10.1007/978-1-4419-6612-4_13. Adv Exp Med Biol. 2011. PMID: 21153316 No abstract available.
Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α-induced JNK activation and inflammation.
Liu J, Yan J, Jiang S, Wen J, Chen L, Zhao Y, Lin A. Liu J, et al. Among authors: lin a. Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):191-6. doi: 10.1073/pnas.1105176108. Epub 2011 Dec 19. Proc Natl Acad Sci U S A. 2012. PMID: 22184250 Free PMC article.
Upon TNF-α stimulation, Miz1 rapidly undergoes K48-linked polyubiquitination at Lys388 and Lys472 residues and subsequent proteasomal degradation in a TRAF2-dependent manner. Replacement of Lysine 388 and Lysine 472 by arginines generates a nondegradable Miz1 mutant …
Upon TNF-α stimulation, Miz1 rapidly undergoes K48-linked polyubiquitination at Lys388 and Lys472 residues and subsequent proteasomal degrad …
Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation.
Liu J, Zhao Y, Eilers M, Lin A. Liu J, et al. Among authors: lin a. Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18279-84. doi: 10.1073/pnas.0906328106. Epub 2009 Oct 7. Proc Natl Acad Sci U S A. 2009. PMID: 19815509 Free PMC article.
Proteomics analysis and yeast two-hybrid screening reveal that Miz1 is a JNK-associated protein. The TNF-alpha-induced activation of JNK1 is augmented in Miz1-deficient mouse embryonic fibroblasts (Miz1(-/-) MEFs), but the augmentation is abrogated by reintroduction of Miz …
Proteomics analysis and yeast two-hybrid screening reveal that Miz1 is a JNK-associated protein. The TNF-alpha-induced activation of …
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