Lin G - Search Results

1

Structure of the full-length glucagon class B G-protein-coupled receptor.

Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Wu X, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Zhao Q, Jiang H, Wang MW, Wu B. Zhang H, et al. Among authors: lin g. Nature. 2017 Jun 8;546(7657):259-264. doi: 10.1038/nature22363. Epub 2017 May 17. Nature. 2017. PMID: 28514451 Free PMC article.

2

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.

Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC. Song G, et al. Among authors: lin g. Nature. 2017 Jun 8;546(7657):312-315. doi: 10.1038/nature22378. Epub 2017 May 17. Nature. 2017. PMID: 28514449

3

Full-length human GLP-1 receptor structure without orthosteric ligands.

Wu F, Yang L, Hang K, Laursen M, Wu L, Han GW, Ren Q, Roed NK, Lin G, Hanson MA, Jiang H, Wang MW, Reedtz-Runge S, Song G, Stevens RC. Wu F, et al. Among authors: lin g. Nat Commun. 2020 Mar 9;11(1):1272. doi: 10.1038/s41467-020-14934-5. Nat Commun. 2020. PMID: 32152292 Free PMC article.

4

Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide.

Chang R, Zhang X, Qiao A, Dai A, Belousoff MJ, Tan Q, Shao L, Zhong L, Lin G, Liang YL, Ma L, Han S, Yang D, Danev R, Wang MW, Wootten D, Wu B, Sexton PM. Chang R, et al. Among authors: lin g. J Biol Chem. 2020 Jul 10;295(28):9313-9325. doi: 10.1074/jbc.RA120.013793. Epub 2020 May 5. J Biol Chem. 2020. PMID: 32371397 Free PMC article.

5

Characterization of a naturally occurring mutation V368M in the human glucagon receptor and its association with metabolic disorders.

Lin G, Liu Q, Dai A, Cai X, Zhou Q, Wang X, Chen Y, Ye C, Li J, Yang D, Wang MW. Lin G, et al. Biochem J. 2020 Jul 17;477(13):2581-2594. doi: 10.1042/BCJ20200235. Biochem J. 2020. PMID: 32677665

6

Deleterious mutation V369M in the mouse GCGR gene causes abnormal plasma amino acid levels indicative of a possible liver-α-cell axis.

Liu Q, Lin G, Chen Y, Feng W, Xu Y, Lyu J, Yang D, Wang MW. Liu Q, et al. Among authors: lin g. Biosci Rep. 2021 Jun 25;41(6):BSR20210758. doi: 10.1042/BSR20210758. Biosci Rep. 2021. PMID: 34002801 Free PMC article.

7

High-Throughput Screening Campaign Identified a Potential Small Molecule RXFP3/4 Agonist.

Lin G, Feng Y, Cai X, Zhou C, Shao L, Chen Y, Chen L, Liu Q, Zhou Q, Bathgate RAD, Yang D, Wang MW. Lin G, et al. Molecules. 2021 Dec 11;26(24):7511. doi: 10.3390/molecules26247511. Molecules. 2021. PMID: 34946593 Free PMC article.

8

High-throughput screening campaign identifies a small molecule agonist of the relaxin family peptide receptor 4.

Lin GY, Lin L, Cai XQ, Dai AT, Zhu Y, Li J, Liu Q, Yang DH, Bathgate RAD, Wang MW. Lin GY, et al. Acta Pharmacol Sin. 2020 Oct;41(10):1328-1336. doi: 10.1038/s41401-020-0390-x. Epub 2020 Mar 31. Acta Pharmacol Sin. 2020. PMID: 32235863 Free PMC article.

9

Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists.

Lin L, Lin G, Zhou Q, Bathgate RAD, Gong GQ, Yang D, Liu Q, Wang MW. Lin L, et al. Among authors: lin g. Bioorg Chem. 2021 May;110:104782. doi: 10.1016/j.bioorg.2021.104782. Epub 2021 Mar 2. Bioorg Chem. 2021. PMID: 33730669

10

W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway.

Li T, Lin GY, Zhong L, Zhou Y, Wang J, Zhu Y, Feng Y, Cai XQ, Liu Q, Nosjean O, Boutin JA, Renard P, Yang DH, Wang MW. Li T, et al. Acta Pharmacol Sin. 2017 Jul;38(7):1024-1037. doi: 10.1038/aps.2017.15. Epub 2017 May 15. Acta Pharmacol Sin. 2017. PMID: 28502980 Free PMC article.

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