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Interleukin-17 family members and inflammation.
Kolls JK, Lindén A. Kolls JK, et al. Immunity. 2004 Oct;21(4):467-76. doi: 10.1016/j.immuni.2004.08.018. Immunity. 2004. PMID: 15485625 Review.
Interleukin-26: An Emerging Player in Host Defense and Inflammation.
Tengvall S, Che KF, Lindén A. Tengvall S, et al. J Innate Immun. 2016;8(1):15-22. doi: 10.1159/000434646. Epub 2015 Jul 21. J Innate Immun. 2016. PMID: 26202572 Free PMC article. Review.
In conclusion, IL-26 is emerging as a potentially important player in host defense and may also be a pathogenic factor in the chronic inflammatory disorders of humans....
In conclusion, IL-26 is emerging as a potentially important player in host defense and may also be a pathogenic factor in the …
Negative feedback on IL-23 exerted by IL-17A during pulmonary inflammation.
Silverpil E, Wright AK, Hansson M, Jirholt P, Henningsson L, Smith ME, Gordon SB, Iwakura Y, Gjertsson I, Glader P, Lindén A. Silverpil E, et al. Innate Immun. 2013 Oct;19(5):479-92. doi: 10.1177/1753425912470470. Epub 2013 Jan 7. Innate Immun. 2013. PMID: 23295184
We characterized the effect of IL-17A on IL-23 release in several models of pulmonary inflammation, evaluated the presence of IL-17 receptor A (RA) and C (RC) on human alveolar macrophages and assessed the role of the Rho family GTPase Rac1 as a mediator of the effe …
We characterized the effect of IL-17A on IL-23 release in several models of pulmonary inflammation, evaluated the presence of IL-17 receptor …
Interleukin-17 cytokine signalling in patients with asthma.
Lindén A, Dahlén B. Lindén A, et al. Eur Respir J. 2014 Nov;44(5):1319-31. doi: 10.1183/09031936.00002314. Epub 2014 Jun 12. Eur Respir J. 2014. PMID: 24925921 Review.
Asthma remains a global health problem and, therefore, more effective pharmacotherapy is needed. This is particularly true for chronic and severe asthma. ...There is a need for new and well-powered clinical investigations of signalling via IL-17 cytokines in this cl …
Asthma remains a global health problem and, therefore, more effective pharmacotherapy is needed. This is particularly true for chroni …
Interleukin-17A during local and systemic Staphylococcus aureus-induced arthritis in mice.
Henningsson L, Jirholt P, Lindholm C, Eneljung T, Silverpil E, Iwakura Y, Linden A, Gjertsson I. Henningsson L, et al. Infect Immun. 2010 Sep;78(9):3783-90. doi: 10.1128/IAI.00385-10. Epub 2010 Jun 28. Infect Immun. 2010. PMID: 20584972 Free PMC article.
Interleukin-17 as a drug target in human disease.
Ivanov S, Lindén A. Ivanov S, et al. Trends Pharmacol Sci. 2009 Feb;30(2):95-103. doi: 10.1016/j.tips.2008.11.004. Epub 2009 Jan 21. Trends Pharmacol Sci. 2009. PMID: 19162337 Review.
Currently believed to be produced mainly by a specific subset of CD4 cells, named Th-17 cells, IL-17 is functionally located at the interface of innate and acquired immunity. ...Furthermore, there is growing evidence that targeting IL-17 signaling might prove useful in …
Currently believed to be produced mainly by a specific subset of CD4 cells, named Th-17 cells, IL-17 is functionally located at the i …
Interleukin-17 and airway remodelling.
Lindén A. Lindén A. Pulm Pharmacol Ther. 2006;19(1):47-50. doi: 10.1016/j.pupt.2005.02.004. Epub 2005 Apr 26. Pulm Pharmacol Ther. 2006. PMID: 16286237 Review.
Even though there are indications of association with specific airway diseases, there is still no final proof that IL-17A plays a truly causative pathogenic role. ...If this is the case, then IL-17A may constitute a useful target for pharmacotherapeutic intervention …
Even though there are indications of association with specific airway diseases, there is still no final proof that IL-17A plays a tru …
Rationale for targeting interleukin-17 in the lungs.
Lindén A. Lindén A. Curr Opin Investig Drugs. 2003 Nov;4(11):1304-12. Curr Opin Investig Drugs. 2003. PMID: 14758769 Review.
Neutrophils, interleukin-17A and lung disease.
Lindén A, Laan M, Anderson GP. Lindén A, et al. Eur Respir J. 2005 Jan;25(1):159-72. doi: 10.1183/09031936.04.00032904. Eur Respir J. 2005. PMID: 15640338 Review.
It is now established that an excessive and sustained mobilisation of neutrophils is a hallmark of several chronic inflammatory lung disorders, including severe obstructive lung disease. This article reviews evidence that the cytokine interleukin (IL)-17A is a major …
It is now established that an excessive and sustained mobilisation of neutrophils is a hallmark of several chronic inflammatory lung …
Airway neutrophils and interleukin-17.
Lindén A, Hoshino H, Laan M. Lindén A, et al. Eur Respir J. 2000 May;15(5):973-7. doi: 10.1034/j.1399-3003.2000.15e28.x. Eur Respir J. 2000. PMID: 10853869 Review.
Clinical studies are needed to evaluate whether or not targeting these mechanisms can provide a useful pharmacotherapeutical approach against exaggerated mobilization of neutrophils in obstructive airways disease....
Clinical studies are needed to evaluate whether or not targeting these mechanisms can provide a useful pharmacotherapeutical approach …
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