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CRISPR RNA-guided activation of endogenous human genes.
Maeder ML, Linder SJ, Cascio VM, Fu Y, Ho QH, Joung JK. Maeder ML, et al. Among authors: linder sj. Nat Methods. 2013 Oct;10(10):977-9. doi: 10.1038/nmeth.2598. Epub 2013 Jul 25. Nat Methods. 2013. PMID: 23892898 Free PMC article.
Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells.
Linder SJ, Bernasocchi T, Martínez-Pastor B, Sullivan KD, Galbraith MD, Lewis CA, Ferrer CM, Boon R, Silveira GG, Cho HM, Vidoudez C, Shroff S, Oliveira-Costa JP, Ross KN, Massri R, Matoba Y, Kim E, Rueda BR, Stott SL, Gottlieb E, Espinosa JM, Mostoslavsky R. Linder SJ, et al. Nat Metab. 2023 Dec;5(12):2131-2147. doi: 10.1038/s42255-023-00919-3. Epub 2023 Nov 13. Nat Metab. 2023. PMID: 37957387