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PSPN/GFRalpha4 has a significantly weaker capacity than GDNF/GFRalpha1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth.
Yang J, Lindahl M, Lindholm P, Virtanen H, Coffey E, Runeberg-Roos P, Saarma M. Yang J, et al. FEBS Lett. 2004 Jul 2;569(1-3):267-71. doi: 10.1016/j.febslet.2004.06.007. FEBS Lett. 2004. PMID: 15225646
Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.
Lindholm P, Voutilainen MH, Laurén J, Peränen J, Leppänen VM, Andressoo JO, Lindahl M, Janhunen S, Kalkkinen N, Timmusk T, Tuominen RK, Saarma M. Lindholm P, et al. Nature. 2007 Jul 5;448(7149):73-7. doi: 10.1038/nature05957. Nature. 2007. PMID: 17611540
MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain.
Lindholm P, Peränen J, Andressoo JO, Kalkkinen N, Kokaia Z, Lindvall O, Timmusk T, Saarma M. Lindholm P, et al. Mol Cell Neurosci. 2008 Nov;39(3):356-71. doi: 10.1016/j.mcn.2008.07.016. Epub 2008 Jul 30. Mol Cell Neurosci. 2008. PMID: 18718866
The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional.
Parkash V, Lindholm P, Peränen J, Kalkkinen N, Oksanen E, Saarma M, Leppänen VM, Goldman A. Parkash V, et al. Protein Eng Des Sel. 2009 Apr;22(4):233-41. doi: 10.1093/protein/gzn080. Epub 2009 Mar 3. Protein Eng Des Sel. 2009. PMID: 19258449
Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease.
Voutilainen MH, Bäck S, Pörsti E, Toppinen L, Lindgren L, Lindholm P, Peränen J, Saarma M, Tuominen RK. Voutilainen MH, et al. J Neurosci. 2009 Jul 29;29(30):9651-9. doi: 10.1523/JNEUROSCI.0833-09.2009. J Neurosci. 2009. PMID: 19641128 Free PMC article.
Regulation of brain-derived neurotrophic factor (BDNF) and cerebral dopamine neurotrophic factor (CDNF) by anti-parkinsonian drug therapy in vivo.
Gyárfás T, Knuuttila J, Lindholm P, Rantamäki T, Castrén E. Gyárfás T, et al. Cell Mol Neurobiol. 2010 Apr;30(3):361-8. doi: 10.1007/s10571-009-9458-3. Epub 2009 Sep 24. Cell Mol Neurobiol. 2010. PMID: 19777340

Selegiline treatment significantly increased BDNF levels in the anterior cingulate cortex (1.55 +/- 0.22, P < 0.05, Student's t-test). In the striatum, selegiline increased BDNF content by 32%, but this change did not reach statistical significance (1.32 +/- 0.15, P

Selegiline treatment significantly increased BDNF levels in the anterior cingulate cortex (1.55 +/- 0.22, P < 0.05, Student's t-te

Novel CDNF/MANF family of neurotrophic factors.
Lindholm P, Saarma M. Lindholm P, et al. Dev Neurobiol. 2010 Apr;70(5):360-71. doi: 10.1002/dneu.20760. Dev Neurobiol. 2010. PMID: 20186704 Review.
Mesencephalic astrocyte-derived neurotrophic factor (MANF) has a unique mechanism to rescue apoptotic neurons.
Hellman M, Arumäe U, Yu LY, Lindholm P, Peränen J, Saarma M, Permi P. Hellman M, et al. J Biol Chem. 2011 Jan 28;286(4):2675-80. doi: 10.1074/jbc.M110.146738. Epub 2010 Nov 3. J Biol Chem. 2011. PMID: 21047780 Free PMC article.
Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease.
Voutilainen MH, Bäck S, Peränen J, Lindholm P, Raasmaja A, Männistö PT, Saarma M, Tuominen RK. Voutilainen MH, et al. Exp Neurol. 2011 Mar;228(1):99-108. doi: 10.1016/j.expneurol.2010.12.013. Epub 2010 Dec 24. Exp Neurol. 2011. PMID: 21185834
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