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Year Number of Results
2002 10
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147 results

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Page 1
Recruitment of FBXO22 for targeted degradation of NSD2.
Nie DY, Tabor JR, Li J, Kutera M, St-Germain J, Hanley RP, Wolf E, Paulakonis E, Kenney TMG, Duan S, Shrestha S, Owens DDG, Maitland MER, Pon A, Szewczyk M, Lamberto AJ, Menes M, Li F, Penn LZ, Barsyte-Lovejoy D, Brown NG, Barsotti AM, Stamford AW, Collins JL, Wilson DJ, Raught B, Licht JD, James LI, Arrowsmith CH. Nie DY, et al. Among authors: james li. Nat Chem Biol. 2024 Dec;20(12):1597-1607. doi: 10.1038/s41589-024-01660-y. Epub 2024 Jul 4. Nat Chem Biol. 2024. PMID: 38965384 Free PMC article.
Target class drug discovery.
Barnash KD, James LI, Frye SV. Barnash KD, et al. Among authors: james li. Nat Chem Biol. 2017 Sep 19;13(10):1053-1056. doi: 10.1038/nchembio.2473. Nat Chem Biol. 2017. PMID: 28926557 Free PMC article.
Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells.
Uguen M, Shell DJ, Silva M, Deng Y, Li F, Szewczyk MM, Yang K, Zhao Y, Stashko MA, Norris-Drouin JL, Waybright JM, Beldar S, Rectenwald JM, Mordant AL, Webb TS, Herring LE, Arrowsmith CH, Ackloo S, Gygi SP, McGinty RK, Barsyte-Lovejoy D, Liu P, Halabelian L, James LI, Pearce KH, Frye SV. Uguen M, et al. Among authors: james li. Nat Commun. 2025 Feb 24;16(1):1905. doi: 10.1038/s41467-025-57005-3. Nat Commun. 2025. PMID: 39994194 Free PMC article.
A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells.
McCole R, Nolan J, Reck DM, Monger C, Rustichelli S, Conway E, Brien GL, Wang C, Deevy O, Neikes HK, Bashore FM, Mooney A, Flavin R, Vandenberghe E, Flanigan SF, Pasini D, Davidovich C, Vermeulen M, James LI, Healy E, Bracken AP. McCole R, et al. Among authors: james li. Cell Rep. 2025 Jan 28;44(1):115192. doi: 10.1016/j.celrep.2024.115192. Epub 2025 Jan 11. Cell Rep. 2025. PMID: 39799569 Free PMC article.
Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22.
Robertson KC, Amann SJ, Liu T, Funk AV, Wang X, Grishkovskaya I, Tabor JR, Norris-Drouin JL, Arrowsmith CH, Collins JL, Emanuele MJ, Haselbach D, James LI, Brown NG. Robertson KC, et al. Among authors: james li. bioRxiv [Preprint]. 2025 Aug 30:2025.08.29.673087. doi: 10.1101/2025.08.29.673087. bioRxiv. 2025. Update in: Nat Commun. 2026 Apr 23. doi: 10.1038/s41467-026-72235-9. PMID: 40909644 Free PMC article. Updated. Preprint.
Chemical probes for methyl lysine reader domains.
James LI, Frye SV. James LI, et al. Curr Opin Chem Biol. 2016 Aug;33:135-41. doi: 10.1016/j.cbpa.2016.06.004. Epub 2016 Jun 25. Curr Opin Chem Biol. 2016. PMID: 27348158 Free PMC article. Review.
147 results