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Directed RNase H Cleavage of Nascent Transcripts Causes Transcription Termination.
Lai F, Damle SS, Ling KK, Rigo F. Lai F, et al. Among authors: ling kk. Mol Cell. 2020 Mar 5;77(5):1032-1043.e4. doi: 10.1016/j.molcel.2019.12.029. Epub 2020 Jan 7. Mol Cell. 2020. PMID: 31924447
Knockdown of GADD34 in neonatal mutant SOD1 mice ameliorates ALS.
Ghadge GD, Sonobe Y, Camarena A, Drigotas C, Rigo F, Ling KK, Roos RP. Ghadge GD, et al. Among authors: ling kk. Neurobiol Dis. 2020 Mar;136:104702. doi: 10.1016/j.nbd.2019.104702. Epub 2019 Dec 16. Neurobiol Dis. 2020. PMID: 31837419 Free article.
Targeted and passive environmental DNA approaches outperform established methods for detection of quagga mussels, Dreissena rostriformis bugensis in flowing water.
Blackman RC, Ling KKS, Harper LR, Shum P, Hänfling B, Lawson-Handley L. Blackman RC, et al. Among authors: ling kks. Ecol Evol. 2020 Oct 29;10(23):13248-13259. doi: 10.1002/ece3.6921. eCollection 2020 Dec. Ecol Evol. 2020. PMID: 33304534 Free PMC article.
Corrigendum to: Pharmacologically-induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset.
Feng Z, Ling KKY, Zhao X, Zhou C, Karp G, Welch EM, Naryshkin N, Ratni H, Chen KS, Metzger F, Paushkin S, Weetall M, Ko CP. Feng Z, et al. Among authors: ling kky. Hum Mol Genet. 2020 Nov 17:ddaa247. doi: 10.1093/hmg/ddaa247. Online ahead of print. Hum Mol Genet. 2020. PMID: 33201218 No abstract available.
Minor snRNA gene delivery improves the loss of proprioceptive synapses on SMA motor neurons.
Osman EY, Van Alstyne M, Yen PF, Lotti F, Feng Z, Ling KK, Ko CP, Pellizzoni L, Lorson CL. Osman EY, et al. Among authors: ling kk. JCI Insight. 2020 Jun 18;5(12):e130574. doi: 10.1172/jci.insight.130574. JCI Insight. 2020. PMID: 32516136 Free PMC article.
NCALD Antisense Oligonucleotide Therapy in Addition to Nusinersen further Ameliorates Spinal Muscular Atrophy in Mice.
Torres-Benito L, Schneider S, Rombo R, Ling KK, Grysko V, Upadhyay A, Kononenko NL, Rigo F, Bennett CF, Wirth B. Torres-Benito L, et al. Among authors: ling kk. Am J Hum Genet. 2019 Jul 3;105(1):221-230. doi: 10.1016/j.ajhg.2019.05.008. Epub 2019 Jun 20. Am J Hum Genet. 2019. PMID: 31230718 Free PMC article.
Antisense-mediated reduction of EphA4 in the adult CNS does not improve the function of mice with amyotrophic lateral sclerosis.
Ling KK, Jackson M, Alkam D, Liu D, Allaire N, Sun C, Kiaei M, McCampbell A, Rigo F. Ling KK, et al. Neurobiol Dis. 2018 Jun;114:174-183. doi: 10.1016/j.nbd.2018.03.002. Epub 2018 Mar 6. Neurobiol Dis. 2018. PMID: 29518482
Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease.
Fil D, DeLoach A, Yadav S, Alkam D, MacNicol M, Singh A, Compadre CM, Goellner JJ, O'Brien CA, Fahmi T, Basnakian AG, Calingasan NY, Klessner JL, Beal FM, Peters OM, Metterville J, Brown RH Jr, Ling KKY, Rigo F, Ozdinler PH, Kiaei M. Fil D, et al. Among authors: ling kky. Hum Mol Genet. 2017 Feb 15;26(4):686-701. doi: 10.1093/hmg/ddw429. Hum Mol Genet. 2017. PMID: 28040732 Free PMC article.
Pharmacokinetics, pharmacodynamics, and efficacy of a small-molecule SMN2 splicing modifier in mouse models of spinal muscular atrophy.
Zhao X, Feng Z, Ling KK, Mollin A, Sheedy J, Yeh S, Petruska J, Narasimhan J, Dakka A, Welch EM, Karp G, Chen KS, Metzger F, Ratni H, Lotti F, Tisdale S, Naryshkin NA, Pellizzoni L, Paushkin S, Ko CP, Weetall M. Zhao X, et al. Among authors: ling kk. Hum Mol Genet. 2016 May 15;25(10):1885-1899. doi: 10.1093/hmg/ddw062. Epub 2016 Feb 29. Hum Mol Genet. 2016. PMID: 26931466 Free PMC article.
Pharmacologically induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset.
Feng Z, Ling KK, Zhao X, Zhou C, Karp G, Welch EM, Naryshkin N, Ratni H, Chen KS, Metzger F, Paushkin S, Weetall M, Ko CP. Feng Z, et al. Among authors: ling kk. Hum Mol Genet. 2016 Mar 1;25(5):964-75. doi: 10.1093/hmg/ddv629. Epub 2016 Jan 11. Hum Mol Genet. 2016. PMID: 26758873
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