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Linked dimensions of psychopathology and connectivity in functional brain networks.
Xia CH, Ma Z, Ciric R, Gu S, Betzel RF, Kaczkurkin AN, Calkins ME, Cook PA, García de la Garza A, Vandekar SN, Cui Z, Moore TM, Roalf DR, Ruparel K, Wolf DH, Davatzikos C, Gur RC, Gur RE, Shinohara RT, Bassett DS, Satterthwaite TD. Xia CH, et al. Nat Commun. 2018 Aug 1;9(1):3003. doi: 10.1038/s41467-018-05317-y. Nat Commun. 2018. PMID: 30068943 Free PMC article.
This analysis reveals correlated patterns of functional connectivity and psychiatric symptoms. We find that four dimensions of psychopathology - mood, psychosis, fear, and externalizing behavior - are associated (r = 0.68-0.71) with distinct patterns o …
This analysis reveals correlated patterns of functional connectivity and psychiatric symptoms. We find that four dimensions
Associations Between Resting-State Functional Connectivity and a Hierarchical Dimensional Structure of Psychopathology in Middle Childhood.
Karcher NR, Michelini G, Kotov R, Barch DM. Karcher NR, et al. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 May;6(5):508-517. doi: 10.1016/j.bpsc.2020.09.008. Epub 2020 Sep 17. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021. PMID: 33229246
The present study is the first to examine associations between dimensions from a hierarchical structure and resting-state functional connectivity (RSFC) networks. ...Analyses revealed robust associations between the neurodevelopmental dimension
The present study is the first to examine associations between dimensions from a hierarchical structure and resting-state function
Toward a Neural Model of the Openness-Psychoticism Dimension: Functional Connectivity in the Default and Frontoparietal Control Networks.
Blain SD, Grazioplene RG, Ma Y, DeYoung CG. Blain SD, et al. Schizophr Bull. 2020 Apr 10;46(3):540-551. doi: 10.1093/schbul/sbz103. Schizophr Bull. 2020. PMID: 31603227 Free PMC article.
We tested the hypothesis that functional connectivity of the default and frontoparietal networks is a neural correlate of the openness-psychoticism dimension. ...We propose a model of psychosis risk that highlights roles of the default and frontopariet …
We tested the hypothesis that functional connectivity of the default and frontoparietal networks is a neural correlate …
Intrinsic Connectivity Patterns of Task-Defined Brain Networks Allow Individual Prediction of Cognitive Symptom Dimension of Schizophrenia and Are Linked to Molecular Architecture.
Chen J, Müller VI, Dukart J, Hoffstaedter F, Baker JT, Holmes AJ, Vatansever D, Nickl-Jockschat T, Liu X, Derntl B, Kogler L, Jardri R, Gruber O, Aleman A, Sommer IE, Eickhoff SB, Patil KR. Chen J, et al. Biol Psychiatry. 2021 Feb 1;89(3):308-319. doi: 10.1016/j.biopsych.2020.09.024. Epub 2020 Oct 3. Biol Psychiatry. 2021. PMID: 33357631 Free PMC article.
BACKGROUND: Despite the marked interindividual variability in the clinical presentation of schizophrenia, the extent to which individual dimensions of psychopathology relate to the functional variability in brain networks among patients remains …
BACKGROUND: Despite the marked interindividual variability in the clinical presentation of schizophrenia, the extent to which individual …
Brain-behaviour modes of covariation in healthy and clinically depressed young people.
Mihalik A, Ferreira FS, Rosa MJ, Moutoussis M, Ziegler G, Monteiro JM, Portugal L, Adams RA, Romero-Garcia R, Vértes PE, Kitzbichler MG, Váša F, Vaghi MM, Bullmore ET, Fonagy P, Goodyer IM, Jones PB; NSPN Consortium, Dolan R, Mourão-Miranda J. Mihalik A, et al. Sci Rep. 2019 Aug 8;9(1):11536. doi: 10.1038/s41598-019-47277-3. Sci Rep. 2019. PMID: 31395894 Free PMC article.
Understanding how variations in dimensions of psychometrics, IQ and demographics relate to changes in brain connectivity during the critical developmental period of adolescence and early adulthood is a major challenge. ...Interestingly, both modes showed an a …
Understanding how variations in dimensions of psychometrics, IQ and demographics relate to changes in brain connectivity
Somatosensory-Motor Dysconnectivity Spans Multiple Transdiagnostic Dimensions of Psychopathology.
Kebets V, Holmes AJ, Orban C, Tang S, Li J, Sun N, Kong R, Poldrack RA, Yeo BTT. Kebets V, et al. Biol Psychiatry. 2019 Nov 15;86(10):779-791. doi: 10.1016/j.biopsych.2019.06.013. Epub 2019 Jun 25. Biol Psychiatry. 2019. PMID: 31515054 Free article.
METHODS: A multivariate data-driven approach (partial least squares) was used to identify latent components linking a large set of clinical, cognitive, and personality measures to whole-brain resting-state functional connectivity patterns across 224 pa …
METHODS: A multivariate data-driven approach (partial least squares) was used to identify latent components linking a large set of cl …
Serotonin transporter gene polymorphism (5-HTTLPR) influences trait anxiety by modulating the functional connectivity between the amygdala and insula in Han Chinese males.
Zhang L, Liu L, Li X, Song Y, Liu J. Zhang L, et al. Hum Brain Mapp. 2015 Jul;36(7):2732-42. doi: 10.1002/hbm.22803. Epub 2015 Apr 2. Hum Brain Mapp. 2015. PMID: 25833281 Free PMC article.
A functional polymorphism (5-hydroxytryptamine transporter linked polymorphic region [5-HTTLPR]) in the promoter region of human serotonin transporter gene has been found to be associated with several dimensions of neuroticism and psychopathology, espe …
A functional polymorphism (5-hydroxytryptamine transporter linked polymorphic region [5-HTTLPR]) in the promoter region of hum …
Fronto-temporal dysfunction in schizophrenia: A selective review.
John JP. John JP. Indian J Psychiatry. 2009 Jul-Sep;51(3):180-90. doi: 10.4103/0019-5545.55084. Indian J Psychiatry. 2009. PMID: 19881045 Free PMC article.
Executive function tests as well as EEG spectral power and coherence studies revealed that the symptom dimensions of schizophrenia could be linked to specific neural correlates. ...Overall, our findings highlight the potential significance of linking t …
Executive function tests as well as EEG spectral power and coherence studies revealed that the symptom dimensions of schizophr …