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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1913 1
1932 2
1942 1
1945 2
1946 3
1947 5
1948 5
1949 3
1950 4
1951 6
1952 6
1953 9
1954 10
1955 10
1956 9
1957 9
1958 15
1959 13
1960 21
1961 13
1962 26
1963 77
1964 125
1965 73
1966 63
1967 62
1968 71
1969 82
1970 86
1971 78
1972 84
1973 89
1974 81
1975 206
1976 175
1977 184
1978 158
1979 185
1980 214
1981 203
1982 228
1983 248
1984 283
1985 292
1986 315
1987 374
1988 338
1989 368
1990 402
1991 385
1992 418
1993 422
1994 457
1995 456
1996 405
1997 448
1998 436
1999 507
2000 581
2001 554
2002 575
2003 615
2004 600
2005 663
2006 632
2007 708
2008 750
2009 742
2010 723
2011 804
2012 890
2013 927
2014 922
2015 943
2016 918
2017 964
2018 952
2019 1027
2020 1184
2021 1211
2022 1269
2023 1235
2024 405

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Search Results

27,568 results

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Page 1
Linoleic acid potentiates CD8(+) T cell metabolic fitness and antitumor immunity.
Nava Lauson CB, Tiberti S, Corsetto PA, Conte F, Tyagi P, Machwirth M, Ebert S, Loffreda A, Scheller L, Sheta D, Mokhtari Z, Peters T, Raman AT, Greco F, Rizzo AM, Beilhack A, Signore G, Tumino N, Vacca P, McDonnell LA, Raimondi A, Greenberg PD, Huppa JB, Cardaci S, Caruana I, Rodighiero S, Nezi L, Manzo T. Nava Lauson CB, et al. Cell Metab. 2023 Apr 4;35(4):633-650.e9. doi: 10.1016/j.cmet.2023.02.013. Epub 2023 Mar 9. Cell Metab. 2023. PMID: 36898381 Free article.
However, the extent to which lipids can affect the CTL functions and fate remains unexplored. Here, we show that linoleic acid (LA) is a major positive regulator of CTL activity by improving metabolic fitness, preventing exhaustion, and stimulating a memory-like phe …
However, the extent to which lipids can affect the CTL functions and fate remains unexplored. Here, we show that linoleic acid …
Linoleic acid.
Whelan J, Fritsche K. Whelan J, et al. Adv Nutr. 2013 May 1;4(3):311-2. doi: 10.3945/an.113.003772. Adv Nutr. 2013. PMID: 23674797 Free PMC article. Review. No abstract available.
Lipolysis-derived linoleic acid drives beige fat progenitor cell proliferation.
Abe I, Oguri Y, Verkerke ARP, Monteiro LB, Knuth CM, Auger C, Qiu Y, Westcott GP, Cinti S, Shinoda K, Jeschke MG, Kajimura S. Abe I, et al. Dev Cell. 2022 Dec 5;57(23):2623-2637.e8. doi: 10.1016/j.devcel.2022.11.007. Dev Cell. 2022. PMID: 36473459 Free PMC article.
A subset of adipocyte progenitors, as marked by cell surface markers PDGFRalpha or Sca1 and CD81, harbored cristae-rich mitochondria and actively imported linoleic acid via a fatty acid transporter CD36. Linoleic acid not only was oxidized as fu …
A subset of adipocyte progenitors, as marked by cell surface markers PDGFRalpha or Sca1 and CD81, harbored cristae-rich mitochondria and act …
Conjugated Linoleic Acid Effects on Cancer, Obesity, and Atherosclerosis: A Review of Pre-Clinical and Human Trials with Current Perspectives.
den Hartigh LJ. den Hartigh LJ. Nutrients. 2019 Feb 11;11(2):370. doi: 10.3390/nu11020370. Nutrients. 2019. PMID: 30754681 Free PMC article. Review.
Therefore, alternative approaches to achieve long term sustainable weight loss are urgently needed. Conjugated linoleic acid (CLA), a fatty acid found naturally in ruminant animal food products, has been identified as a potential anti-obesogenic agent, with s …
Therefore, alternative approaches to achieve long term sustainable weight loss are urgently needed. Conjugated linoleic acid ( …
Linoleic acid and the regulation of glucose homeostasis: A review of the evidence.
Hamilton JS, Klett EL. Hamilton JS, et al. Prostaglandins Leukot Essent Fatty Acids. 2021 Dec;175:102366. doi: 10.1016/j.plefa.2021.102366. Epub 2021 Oct 29. Prostaglandins Leukot Essent Fatty Acids. 2021. PMID: 34763302 Free PMC article. Review.
The consumption of linoleic acid (LA, omega-6 18:2), the most common omega-6 polyunsaturated fatty acid (PUFA) in the Modern Western diet (MWD), has significantly increased over the last century in tandem with unprecedented incidence of chronic metabolic dise …
The consumption of linoleic acid (LA, omega-6 18:2), the most common omega-6 polyunsaturated fatty acid (PUFA) in the M …
Linoleic Acid: A Narrative Review of the Effects of Increased Intake in the Standard American Diet and Associations with Chronic Disease.
Mercola J, D'Adamo CR. Mercola J, et al. Nutrients. 2023 Jul 13;15(14):3129. doi: 10.3390/nu15143129. Nutrients. 2023. PMID: 37513547 Free PMC article. Review.
The intake of linoleic acid (LA) has increased dramatically in the standard American diet. ...The goal of this narrative review is to explore the mechanisms that underlie the hypothesis that excessive LA intake may harm human health. While LA is considered to be an …
The intake of linoleic acid (LA) has increased dramatically in the standard American diet. ...The goal of this narrative revie …
The Role of Arachidonic and Linoleic Acid Derivatives in Pathological Pregnancies and the Human Reproduction Process.
Szczuko M, Kikut J, Komorniak N, Bilicki J, Celewicz Z, Ziętek M. Szczuko M, et al. Int J Mol Sci. 2020 Dec 17;21(24):9628. doi: 10.3390/ijms21249628. Int J Mol Sci. 2020. PMID: 33348841 Free PMC article. Review.
The aim of the available literature review was to focus on the role of the proinflammatory mediators of AA and LA derivatives in pathological conditions related to reproduction and pregnancy. Arachidonic (AA) and linoleic acid (LA) derivatives play important roles i …
The aim of the available literature review was to focus on the role of the proinflammatory mediators of AA and LA derivatives in pathologica …
Linoleic acid and the pathogenesis of obesity.
Naughton SS, Mathai ML, Hryciw DH, McAinch AJ. Naughton SS, et al. Prostaglandins Other Lipid Mediat. 2016 Sep;125:90-9. doi: 10.1016/j.prostaglandins.2016.06.003. Epub 2016 Jun 24. Prostaglandins Other Lipid Mediat. 2016. PMID: 27350414 Review.
These nutrition transitions are typified by an increased intake of high linoleic acid (LA) plant oils, due to their abundance and low price, resulting in an increase in the PUFA n-6:n-3 ratio. This increase in LA above what is estimated to be required is hypothesise …
These nutrition transitions are typified by an increased intake of high linoleic acid (LA) plant oils, due to their abundance …
Staged suppression of microglial autophagy facilitates regeneration in CNS demyelination by enhancing the production of linoleic acid.
Zhou LQ, Dong MH, Hu ZW, Tang Y, Chu YH, Chen M, Yang S, Chen Z, Wu LJ, Wang W, Qin C, Tian DS. Zhou LQ, et al. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2209990120. doi: 10.1073/pnas.2209990120. Epub 2022 Dec 28. Proc Natl Acad Sci U S A. 2023. PMID: 36577069 Free PMC article.
Combined multi-omics results in vitro further showed that enhanced lipid metabolism, especially the activation of the linoleic acid pathway, underlies this protective effect. Supplementation with conjugated linoleic acid (CLA), both in vivo and in vitr …
Combined multi-omics results in vitro further showed that enhanced lipid metabolism, especially the activation of the linoleic aci …
Dietary linoleic acid and human health: Focus on cardiovascular and cardiometabolic effects.
Marangoni F, Agostoni C, Borghi C, Catapano AL, Cena H, Ghiselli A, La Vecchia C, Lercker G, Manzato E, Pirillo A, Riccardi G, Risé P, Visioli F, Poli A. Marangoni F, et al. Atherosclerosis. 2020 Jan;292:90-98. doi: 10.1016/j.atherosclerosis.2019.11.018. Epub 2019 Nov 15. Atherosclerosis. 2020. PMID: 31785494 Review.
This narrative review aims to discuss the more relevant evidence on the role of linoleic acid (LA), a n-6 essential fatty acid that constitutes the predominant proportion of dietary polyunsaturated fatty acids (PUFA), in cardiovascular health. ...High quality …
This narrative review aims to discuss the more relevant evidence on the role of linoleic acid (LA), a n-6 essential fatty a …
27,568 results
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