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The sheddase ADAM10 is a potent modulator of prion disease.
Altmeppen HC, Prox J, Krasemann S, Puig B, Kruszewski K, Dohler F, Bernreuther C, Hoxha A, Linsenmeier L, Sikorska B, Liberski PP, Bartsch U, Saftig P, Glatzel M. Altmeppen HC, et al. Among authors: linsenmeier l. Elife. 2015 Feb 5;4:e04260. doi: 10.7554/eLife.04260. Elife. 2015. PMID: 25654651 Free PMC article.
Shedding light on prion disease.
Glatzel M, Linsenmeier L, Dohler F, Krasemann S, Puig B, Altmeppen HC. Glatzel M, et al. Among authors: linsenmeier l. Prion. 2015;9(4):244-56. doi: 10.1080/19336896.2015.1065371. Prion. 2015. PMID: 26186508 Free PMC article.
Diverse functions of the prion protein - Does proteolytic processing hold the key?
Linsenmeier L, Altmeppen HC, Wetzel S, Mohammadi B, Saftig P, Glatzel M. Linsenmeier L, et al. Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2128-2137. doi: 10.1016/j.bbamcr.2017.06.022. Epub 2017 Jul 8. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28693923 Free article. Review.
GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice.
Puig B, Altmeppen HC, Linsenmeier L, Chakroun K, Wegwitz F, Piontek UK, Tatzelt J, Bate C, Magnus T, Glatzel M. Puig B, et al. Among authors: linsenmeier l. PLoS Pathog. 2019 Jan 4;15(1):e1007520. doi: 10.1371/journal.ppat.1007520. eCollection 2019 Jan. PLoS Pathog. 2019. PMID: 30608982 Free PMC article.
Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation.
Mohammadi B, Linsenmeier L, Shafiq M, Puig B, Galliciotti G, Giudici C, Willem M, Eden T, Koch-Nolte F, Lin YH, Tatzelt J, Glatzel M, Altmeppen HC. Mohammadi B, et al. Among authors: linsenmeier l. Mol Neurobiol. 2020 Jun;57(6):2812-2829. doi: 10.1007/s12035-020-01917-2. Epub 2020 May 4. Mol Neurobiol. 2020. PMID: 32367491 Free PMC article.
Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions.
Aguilar-Calvo P, Sevillano AM, Bapat J, Soldau K, Sandoval DR, Altmeppen HC, Linsenmeier L, Pizzo DP, Geschwind MD, Sanchez H, Appleby BS, Cohen ML, Safar JG, Edland SD, Glatzel M, Nilsson KPR, Esko JD, Sigurdson CJ. Aguilar-Calvo P, et al. Among authors: linsenmeier l. Acta Neuropathol. 2020 Mar;139(3):527-546. doi: 10.1007/s00401-019-02085-x. Epub 2019 Oct 31. Acta Neuropathol. 2020. PMID: 31673874 Free PMC article.
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies.
Linsenmeier L, Mohammadi B, Shafiq M, Frontzek K, Bär J, Shrivastava AN, Damme M, Song F, Schwarz A, Da Vela S, Massignan T, Jung S, Correia A, Schmitz M, Puig B, Hornemann S, Zerr I, Tatzelt J, Biasini E, Saftig P, Schweizer M, Svergun D, Amin L, Mazzola F, Varani L, Thapa S, Gilch S, Schätzl H, Harris DA, Triller A, Mikhaylova M, Aguzzi A, Altmeppen HC, Glatzel M. Linsenmeier L, et al. Sci Adv. 2021 Nov 26;7(48):eabj1826. doi: 10.1126/sciadv.abj1826. Epub 2021 Nov 24. Sci Adv. 2021. PMID: 34818048 Free PMC article.
Pharmacological inactivation of the prion protein by targeting a folding intermediate.
Spagnolli G, Massignan T, Astolfi A, Biggi S, Rigoli M, Brunelli P, Libergoli M, Ianeselli A, Orioli S, Boldrini A, Terruzzi L, Bonaldo V, Maietta G, Lorenzo NL, Fernandez LC, Codeseira YB, Tosatto L, Linsenmeier L, Vignoli B, Petris G, Gasparotto D, Pennuto M, Guella G, Canossa M, Altmeppen HC, Lolli G, Biressi S, Pastor MM, Requena JR, Mancini I, Barreca ML, Faccioli P, Biasini E. Spagnolli G, et al. Among authors: linsenmeier l. Commun Biol. 2021 Jan 12;4(1):62. doi: 10.1038/s42003-020-01585-x. Commun Biol. 2021. PMID: 33437023 Free PMC article.
12 results