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Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application.
Jackson AL, Linsley PS. Jackson AL, et al. Among authors: linsley ps. Nat Rev Drug Discov. 2010 Jan;9(1):57-67. doi: 10.1038/nrd3010. Nat Rev Drug Discov. 2010. PMID: 20043028 Review.
An efficient and fully automated high-throughput transfection method for genome-scale siRNA screens.
Chung N, Locco L, Huff KW, Bartz S, Linsley PS, Ferrer M, Strulovici B. Chung N, et al. Among authors: linsley ps. J Biomol Screen. 2008 Feb;13(2):142-8. doi: 10.1177/1087057107312032. Epub 2008 Jan 23. J Biomol Screen. 2008. PMID: 18216392
Designing siRNA that distinguish between genes that differ by a single nucleotide.
Schwarz DS, Ding H, Kennington L, Moore JT, Schelter J, Burchard J, Linsley PS, Aronin N, Xu Z, Zamore PD. Schwarz DS, et al. Among authors: linsley ps. PLoS Genet. 2006 Sep 8;2(9):e140. doi: 10.1371/journal.pgen.0020140. Epub 2006 Jul 24. PLoS Genet. 2006. PMID: 16965178 Free PMC article.
PPARalpha siRNA-treated expression profiles uncover the causal sufficiency network for compound-induced liver hypertrophy.
Dai X, De Souza AT, Dai H, Lewis DL, Lee CK, Spencer AG, Herweijer H, Hagstrom JE, Linsley PS, Bassett DE, Ulrich RG, He YD. Dai X, et al. Among authors: linsley ps. PLoS Comput Biol. 2007 Mar 2;3(3):e30. doi: 10.1371/journal.pcbi.0030030. Epub 2007 Jan 2. PLoS Comput Biol. 2007. PMID: 17335344 Free PMC article.
Hidden reach of the micromanagers.
Linsley PS, Jackson AL. Linsley PS, et al. BMC Biol. 2010 May 11;8:53. doi: 10.1186/1741-7007-8-53. BMC Biol. 2010. PMID: 20529236 Free PMC article. Review.
Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1.
Vickers TA, Lima WF, Wu H, Nichols JG, Linsley PS, Crooke ST. Vickers TA, et al. Among authors: linsley ps. Nucleic Acids Res. 2009 Nov;37(20):6927-41. doi: 10.1093/nar/gkp735. Epub 2009 Sep 18. Nucleic Acids Res. 2009. PMID: 19767612 Free PMC article.
Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies.
Kittler R, Surendranath V, Heninger AK, Slabicki M, Theis M, Putz G, Franke K, Caldarelli A, Grabner H, Kozak K, Wagner J, Rees E, Korn B, Frenzel C, Sachse C, Sönnichsen B, Guo J, Schelter J, Burchard J, Linsley PS, Jackson AL, Habermann B, Buchholz F. Kittler R, et al. Among authors: linsley ps. Nat Methods. 2007 Apr;4(4):337-44. doi: 10.1038/nmeth1025. Epub 2007 Mar 11. Nat Methods. 2007. PMID: 17351622
Synthetic shRNAs as potent RNAi triggers.
Siolas D, Lerner C, Burchard J, Ge W, Linsley PS, Paddison PJ, Hannon GJ, Cleary MA. Siolas D, et al. Among authors: linsley ps. Nat Biotechnol. 2005 Feb;23(2):227-31. doi: 10.1038/nbt1052. Epub 2004 Dec 26. Nat Biotechnol. 2005. PMID: 15619616
A microRNA component of the p53 tumour suppressor network.
He L, He X, Lim LP, de Stanchina E, Xuan Z, Liang Y, Xue W, Zender L, Magnus J, Ridzon D, Jackson AL, Linsley PS, Chen C, Lowe SW, Cleary MA, Hannon GJ. He L, et al. Among authors: linsley ps. Nature. 2007 Jun 28;447(7148):1130-4. doi: 10.1038/nature05939. Epub 2007 Jun 6. Nature. 2007. PMID: 17554337 Free PMC article.
A large-scale RNAi screen in human cells identifies new components of the p53 pathway.
Berns K, Hijmans EM, Mullenders J, Brummelkamp TR, Velds A, Heimerikx M, Kerkhoven RM, Madiredjo M, Nijkamp W, Weigelt B, Agami R, Ge W, Cavet G, Linsley PS, Beijersbergen RL, Bernards R. Berns K, et al. Among authors: linsley ps. Nature. 2004 Mar 25;428(6981):431-7. doi: 10.1038/nature02371. Nature. 2004. PMID: 15042092
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