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Metabolite proofreading, a neglected aspect of intermediary metabolism.
Van Schaftingen E, Rzem R, Marbaix A, Collard F, Veiga-da-Cunha M, Linster CL. Van Schaftingen E, et al. Among authors: linster cl. J Inherit Metab Dis. 2013 May;36(3):427-34. doi: 10.1007/s10545-012-9571-1. Epub 2013 Jan 8. J Inherit Metab Dis. 2013. PMID: 23296366 Review.
A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast.
Collard F, Baldin F, Gerin I, Bolsée J, Noël G, Graff J, Veiga-da-Cunha M, Stroobant V, Vertommen D, Houddane A, Rider MH, Linster CL, Van Schaftingen E, Bommer GT. Collard F, et al. Among authors: linster cl. Nat Chem Biol. 2016 Aug;12(8):601-7. doi: 10.1038/nchembio.2104. Epub 2016 Jun 13. Nat Chem Biol. 2016. PMID: 27294321
Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione.
Peracchi A, Veiga-da-Cunha M, Kuhara T, Ellens KW, Paczia N, Stroobant V, Seliga AK, Marlaire S, Jaisson S, Bommer GT, Sun J, Huebner K, Linster CL, Cooper AJL, Van Schaftingen E. Peracchi A, et al. Among authors: linster cl. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3233-E3242. doi: 10.1073/pnas.1613736114. Epub 2017 Apr 3. Proc Natl Acad Sci U S A. 2017. PMID: 28373563 Free PMC article.
43 results