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33 results
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Metabolite damage and its repair or pre-emption.
Linster CL, Van Schaftingen E, Hanson AD. Linster CL, et al. Nat Chem Biol. 2013 Feb;9(2):72-80. doi: 10.1038/nchembio.1141. Nat Chem Biol. 2013. PMID: 23334546 Review.
Occurrence and subcellular distribution of the NADPHX repair system in mammals.
Marbaix AY, Tyteca D, Niehaus TD, Hanson AD, Linster CL, Van Schaftingen E. Marbaix AY, et al. Among authors: linster cl. Biochem J. 2014 May 15;460(1):49-58. doi: 10.1042/BJ20131482. Biochem J. 2014. PMID: 24611804
A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast.
Collard F, Baldin F, Gerin I, Bolsée J, Noël G, Graff J, Veiga-da-Cunha M, Stroobant V, Vertommen D, Houddane A, Rider MH, Linster CL, Van Schaftingen E, Bommer GT. Collard F, et al. Among authors: linster cl. Nat Chem Biol. 2016 Aug;12(8):601-7. doi: 10.1038/nchembio.2104. Epub 2016 Jun 13. Nat Chem Biol. 2016. PMID: 27294321
Molecular Identification of d-Ribulokinase in Budding Yeast and Mammals.
Singh C, Glaab E, Linster CL. Singh C, et al. Among authors: linster cl. J Biol Chem. 2017 Jan 20;292(3):1005-1028. doi: 10.1074/jbc.M116.760744. Epub 2016 Dec 1. J Biol Chem. 2017. PMID: 27909055 Free PMC article.
Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione.
Peracchi A, Veiga-da-Cunha M, Kuhara T, Ellens KW, Paczia N, Stroobant V, Seliga AK, Marlaire S, Jaisson S, Bommer GT, Sun J, Huebner K, Linster CL, Cooper AJL, Van Schaftingen E. Peracchi A, et al. Among authors: linster cl. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3233-E3242. doi: 10.1073/pnas.1613736114. Epub 2017 Apr 3. Proc Natl Acad Sci U S A. 2017. PMID: 28373563 Free PMC article.
Confronting the catalytic dark matter encoded by sequenced genomes.
Ellens KW, Christian N, Singh C, Satagopam VP, May P, Linster CL. Ellens KW, et al. Among authors: linster cl. Nucleic Acids Res. 2017 Nov 16;45(20):11495-11514. doi: 10.1093/nar/gkx937. Nucleic Acids Res. 2017. PMID: 29059321 Free PMC article.
NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells.
Becker-Kettern J, Paczia N, Conrotte JF, Zhu C, Fiehn O, Jung PP, Steinmetz LM, Linster CL. Becker-Kettern J, et al. Among authors: linster cl. FEBS J. 2018 Sep;285(18):3376-3401. doi: 10.1111/febs.14631. Epub 2018 Aug 27. FEBS J. 2018. PMID: 30098110 Free article.
NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative disorder exacerbated by febrile illnesses.
Van Bergen NJ, Guo Y, Rankin J, Paczia N, Becker-Kettern J, Kremer LS, Pyle A, Conrotte JF, Ellaway C, Procopis P, Prelog K, Homfray T, Baptista J, Baple E, Wakeling M, Massey S, Kay DP, Shukla A, Girisha KM, Lewis LES, Santra S, Power R, Daubeney P, Montoya J, Ruiz-Pesini E, Kovacs-Nagy R, Pritsch M, Ahting U, Thorburn DR, Prokisch H, Taylor RW, Christodoulou J, Linster CL, Ellard S, Hakonarson H. Van Bergen NJ, et al. Among authors: linster cl. Brain. 2019 Jan 1;142(1):50-58. doi: 10.1093/brain/awy310. Brain. 2019. PMID: 30576410
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production.
Michelucci A, Cordes T, Ghelfi J, Pailot A, Reiling N, Goldmann O, Binz T, Wegner A, Tallam A, Rausell A, Buttini M, Linster CL, Medina E, Balling R, Hiller K. Michelucci A, et al. Among authors: linster cl. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7820-5. doi: 10.1073/pnas.1218599110. Epub 2013 Apr 22. Proc Natl Acad Sci U S A. 2013. PMID: 23610393 Free PMC article.
Vitamin C. Biosynthesis, recycling and degradation in mammals.
Linster CL, Van Schaftingen E. Linster CL, et al. FEBS J. 2007 Jan;274(1):1-22. doi: 10.1111/j.1742-4658.2006.05607.x. FEBS J. 2007. PMID: 17222174 Review.
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