Linton KJ - Search Results

1

Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre-messenger RNA splicing.

Byrne JA, Strautnieks SS, Ihrke G, Pagani F, Knisely AS, Linton KJ, Mieli-Vergani G, Thompson RJ. Byrne JA, et al. Among authors: linton kj. Hepatology. 2009 Feb;49(2):553-67. doi: 10.1002/hep.22683. Hepatology. 2009. PMID: 19101985

2

The human bile salt export pump: characterization of substrate specificity and identification of inhibitors.

Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ. Byrne JA, et al. Among authors: linton kj. Gastroenterology. 2002 Nov;123(5):1649-58. doi: 10.1053/gast.2002.36591. Gastroenterology. 2002. PMID: 12404239

3

Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy.

Dixon PH, van Mil SW, Chambers J, Strautnieks S, Thompson RJ, Lammert F, Kubitz R, Keitel V, Glantz A, Mattsson LA, Marschall HU, Molokhia M, Moore GE, Linton KJ, Williamson C. Dixon PH, et al. Among authors: linton kj. Gut. 2009 Apr;58(4):537-44. doi: 10.1136/gut.2008.159541. Epub 2008 Nov 5. Gut. 2009. PMID: 18987030

4

Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4.

Andress EJ, Nicolaou M, Romero MR, Naik S, Dixon PH, Williamson C, Linton KJ. Andress EJ, et al. Among authors: linton kj. Hepatology. 2014 May;59(5):1921-31. doi: 10.1002/hep.26970. Epub 2014 Apr 1. Hepatology. 2014. PMID: 24806754

5

Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking.

Dixon PH, Weerasekera N, Linton KJ, Donaldson O, Chambers J, Egginton E, Weaver J, Nelson-Piercy C, de Swiet M, Warnes G, Elias E, Higgins CF, Johnston DG, McCarthy MI, Williamson C. Dixon PH, et al. Among authors: linton kj. Hum Mol Genet. 2000 May 1;9(8):1209-17. doi: 10.1093/hmg/9.8.1209. Hum Mol Genet. 2000. PMID: 10767346

6

Canalicular ABC transporters and liver disease.

Nicolaou M, Andress EJ, Zolnerciks JK, Dixon PH, Williamson C, Linton KJ. Nicolaou M, et al. Among authors: linton kj. J Pathol. 2012 Jan;226(2):300-15. doi: 10.1002/path.3019. J Pathol. 2012. PMID: 21984474 Review.

7

ABCB4 missense mutations D243A, K435T, G535D, I490T, R545C, and S978P significantly impair the lipid floppase and likely predispose to secondary pathologies in the human population.

Andress EJ, Nicolaou M, McGeoghan F, Linton KJ. Andress EJ, et al. Among authors: linton kj. Cell Mol Life Sci. 2017 Jul;74(13):2513-2524. doi: 10.1007/s00018-017-2472-6. Epub 2017 Feb 20. Cell Mol Life Sci. 2017. PMID: 28220208 Free PMC article.

8

Structure and function of ABC transporters.

Linton KJ. Linton KJ. Physiology (Bethesda). 2007 Apr;22:122-30. doi: 10.1152/physiol.00046.2006. Physiology (Bethesda). 2007. PMID: 17420303 Free article. Review.

9

Lipid flopping in the liver.

Linton KJ. Linton KJ. Biochem Soc Trans. 2015 Oct;43(5):1003-10. doi: 10.1042/BST20150132. Biochem Soc Trans. 2015. PMID: 26517915 Review.

10

The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle.

Zolnerciks JK, Akkaya BG, Snippe M, Chiba P, Seelig A, Linton KJ. Zolnerciks JK, et al. Among authors: linton kj. FASEB J. 2014 Oct;28(10):4335-46. doi: 10.1096/fj.13-245639. Epub 2014 Jul 11. FASEB J. 2014. PMID: 25016028

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