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Pharmacology of L-744,453, a novel nonpeptidyl endothelin antagonist.
Williams DL Jr, Murphy KL, Nolan NA, O'Brien JA, Lis EV Jr, Pettibone DJ, Clineschmidt BV, Krause SM, Veber DF, Naylor EM, Chakravarty PK, Walsh TF, Dhanoa DM, Chen A, Bagley SW, Fitch KJ, Greenlee WJ. Williams DL Jr, et al. Among authors: lis ev jr. Life Sci. 1996;58(14):1149-57. doi: 10.1016/0024-3205(96)00073-2. Life Sci. 1996. PMID: 8614266
Identification of an orally active, nonpeptidyl oxytocin antagonist.
Pettibone DJ, Clineschmidt BV, Kishel MT, Lis EV, Reiss DR, Woyden CJ, Evans BE, Freidinger RM, Veber DF, Cook MJ, et al. Pettibone DJ, et al. Among authors: lis ev. J Pharmacol Exp Ther. 1993 Jan;264(1):308-14. J Pharmacol Exp Ther. 1993. PMID: 8423533
A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066.
Clineschmidt BV, Pettibone DJ, Lotti VJ, Hucker HB, Sweeney BM, Reiss DR, Lis EV, Huff JR, Vacca J. Clineschmidt BV, et al. Among authors: lis ev. J Pharmacol Exp Ther. 1988 Apr;245(1):32-40. J Pharmacol Exp Ther. 1988. PMID: 2896239
Bradykinin agonist activity of a novel, potent oxytocin antagonist.
Pettibone DJ, Clineschmidt BV, Lis EV, Ransom RW, Totaro JA, Young GS, Bock MG, Freidinger RM, Veber DF, Williams PD. Pettibone DJ, et al. Among authors: lis ev. Eur J Pharmacol. 1991 Apr 24;196(3):233-7. doi: 10.1016/0014-2999(91)90435-s. Eur J Pharmacol. 1991. PMID: 1893911
Development of orally active oxytocin antagonists: studies on 1-(1-[4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl]piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines.
Bell IM, Erb JM, Freidinger RM, Gallicchio SN, Guare JP, Guidotti MT, Halpin RA, Hobbs DW, Homnick CF, Kuo MS, Lis EV, Mathre DJ, Michelson SR, Pawluczyk JM, Pettibone DJ, Reiss DR, Vickers S, Williams PD, Woyden CJ. Bell IM, et al. Among authors: lis ev. J Med Chem. 1998 Jun 4;41(12):2146-63. doi: 10.1021/jm9800797. J Med Chem. 1998. PMID: 9622556
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