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Lissencephaly: mechanistic insights from animal models and potential therapeutic strategies.
Wynshaw-Boris A, Pramparo T, Youn YH, Hirotsune S. Wynshaw-Boris A, et al. Semin Cell Dev Biol. 2010 Oct;21(8):823-30. doi: 10.1016/j.semcdb.2010.07.008. Epub 2010 Aug 3. Semin Cell Dev Biol. 2010. PMID: 20688183 Free PMC article. Review.
Lissencephaly is a severe human neuronal migration defect characterized by a smooth cerebral surface, mental retardation and seizures. The two most common genes mutated in patients with lissencephaly are LIS1 and DCX. LIS1 was the first gene clo …
Lissencephaly is a severe human neuronal migration defect characterized by a smooth cerebral surface, mental retardation and seizures …
Role of cytoskeletal abnormalities in the neuropathology and pathophysiology of type I lissencephaly.
Friocourt G, Marcorelles P, Saugier-Veber P, Quille ML, Marret S, Laquerrière A. Friocourt G, et al. Acta Neuropathol. 2011 Feb;121(2):149-70. doi: 10.1007/s00401-010-0768-9. Epub 2010 Nov 3. Acta Neuropathol. 2011. PMID: 21046408 Free PMC article. Review.
Type I lissencephaly or agyria-pachygyria is a rare developmental disorder which results from a defect of neuronal migration. ...The number and heterogeneity of clinical, neuropathological and radiological defects suggest that type I lissencephaly now …
Type I lissencephaly or agyria-pachygyria is a rare developmental disorder which results from a defect of neuronal migration. …
Abnormal cortical development; towards elucidation of the LIS1 gene product function (review).
Reiner O, Sapir T. Reiner O, et al. Int J Mol Med. 1998 May;1(5):849-53. doi: 10.3892/ijmm.1.5.849. Int J Mol Med. 1998. PMID: 9852306 Review.
Lissencephaly is a relatively common brain malformation. Lissencephaly type 1 is characterized by the smooth appearance of the cortex and the presence of four abnormally positioned layers instead of the normal six. ...The gene mutated in …
Lissencephaly is a relatively common brain malformation. Lissencephaly type 1 is characterized by the smooth app …