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Effect of intravenous lipid emulsion on bupivacaine plasma concentration in humans.
Litonius E, Tarkkila P, Neuvonen PJ, Rosenberg PH. Litonius E, et al. Anaesthesia. 2012 Jun;67(6):600-5. doi: 10.1111/j.1365-2044.2012.07056.x. Epub 2012 Feb 21. Anaesthesia. 2012. PMID: 22352703 Clinical Trial.
The effects of intravenous lipid emulsion on hemodynamic recovery and myocardial cell mitochondrial function after bupivacaine toxicity in anesthetized pigs.
Heinonen JA, Schramko AA, Skrifvars MB, Litonius E, Backman JT, Mervaala E, Rosenberg PH. Heinonen JA, et al. Among authors: litonius e. Hum Exp Toxicol. 2017 Apr;36(4):365-375. doi: 10.1177/0960327116650010. Epub 2016 May 24. Hum Exp Toxicol. 2017. PMID: 27222493
Intravenous lipid emulsion for levobupivacaine intoxication in acidotic and hypoxaemic pigs.
Heinonen JA, Skrifvars MB, Haasio J, Backman JT, Rosenberg PH, Litonius E. Heinonen JA, et al. Among authors: litonius e. Anaesth Intensive Care. 2016 Mar;44(2):270-7. doi: 10.1177/0310057X1604400214. Anaesth Intensive Care. 2016. PMID: 27029660 Free article.
Incidence of severe local anaesthetic toxicity and adoption of lipid rescue in Finnish anaesthesia departments in 2011-2013.
Heinonen JA, Litonius E, Pitkänen M, Rosenberg PH. Heinonen JA, et al. Among authors: litonius e. Acta Anaesthesiol Scand. 2015 Sep;59(8):1032-7. doi: 10.1111/aas.12545. Epub 2015 May 4. Acta Anaesthesiol Scand. 2015. PMID: 25939497
Intravenous lipid emulsion only minimally influences bupivacaine and mepivacaine distribution in plasma and does not enhance recovery from intoxication in pigs.
Litonius ES, Niiya T, Neuvonen PJ, Rosenberg PH. Litonius ES, et al. Anesth Analg. 2012 Apr;114(4):901-6. doi: 10.1213/ANE.0b013e3182367a37. Epub 2011 Oct 24. Anesth Analg. 2012. PMID: 22025489
Intravenous lipid emulsion given to volunteers does not affect symptoms of lidocaine brain toxicity.
Heinonen JA, Litonius E, Salmi T, Haasio J, Tarkkila P, Backman JT, Rosenberg PH. Heinonen JA, et al. Among authors: litonius e. Basic Clin Pharmacol Toxicol. 2015 Apr;116(4):378-83. doi: 10.1111/bcpt.12321. Epub 2014 Oct 7. Basic Clin Pharmacol Toxicol. 2015. PMID: 25207682 Free article. Clinical Trial.
Response to 'In Response to "Intravenous Lipid Emulsion Given to Volunteers does not Affect Symptoms of Lidocaine Brain Toxicity"'.
Heinonen JA, Litonius E, Rosenberg PH. Heinonen JA, et al. Among authors: litonius e. Basic Clin Pharmacol Toxicol. 2015 Dec;117(6):362. doi: 10.1111/bcpt.12471. Epub 2015 Sep 11. Basic Clin Pharmacol Toxicol. 2015. PMID: 26360637 Free article. No abstract available.
Intravenous lipid emulsion entraps amitriptyline into plasma and can lower its brain concentration--an experimental intoxication study in pigs.
Heinonen JA, Litonius E, Backman JT, Neuvonen PJ, Rosenberg PH. Heinonen JA, et al. Among authors: litonius e. Basic Clin Pharmacol Toxicol. 2013 Sep;113(3):193-200. doi: 10.1111/bcpt.12082. Epub 2013 May 29. Basic Clin Pharmacol Toxicol. 2013. PMID: 23639060
In vitro and in vivo entrapment of bupivacaine by lipid dispersions.
Litonius E, Lokajova J, Yohannes G, Neuvonen PJ, Holopainen JM, Rosenberg PH, Wiedmer SK. Litonius E, et al. J Chromatogr A. 2012 Sep 7;1254:125-31. doi: 10.1016/j.chroma.2012.07.013. Epub 2012 Jul 11. J Chromatogr A. 2012. PMID: 22832037
Intravenous lipid emulsion sequesters amiodarone in plasma and eliminates its hypotensive action in pigs.
Niiya T, Litonius E, Petäjä L, Neuvonen PJ, Rosenberg PH. Niiya T, et al. Among authors: litonius e. Ann Emerg Med. 2010 Oct;56(4):402-408.e2. doi: 10.1016/j.annemergmed.2010.06.001. Ann Emerg Med. 2010. PMID: 20868908
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