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A clinical overview of WT1 gene mutations.
Little M, Wells C. Little M, et al. Hum Mutat. 1997;9(3):209-25. doi: 10.1002/(SICI)1098-1004(1997)9:3<209::AID-HUMU2>3.0.CO;2-2. Hum Mutat. 1997. PMID: 9090524 Review.
Evidence that WT1 mutations in Denys-Drash syndrome patients may act in a dominant-negative fashion.
Little MH, Williamson KA, Mannens M, Kelsey A, Gosden C, Hastie ND, van Heyningen V. Little MH, et al. Hum Mol Genet. 1993 Mar;2(3):259-64. doi: 10.1093/hmg/2.3.259. Hum Mol Genet. 1993. PMID: 8388765
Molecular genetic evidence for common pathogenesis of childhood and adult Wilms' tumor.
Kozman HM, Clarke JM, Little MH, Smith PJ. Kozman HM, et al. Among authors: little mh. Cancer Genet Cytogenet. 1989 Mar;38(1):121-5. doi: 10.1016/0165-4608(89)90172-6. Cancer Genet Cytogenet. 1989. PMID: 2540899
Equivalent expression of paternally and maternally inherited WT1 alleles in normal fetal tissue and Wilms' tumours.
Little MH, Dunn R, Byrne JA, Seawright A, Smith PJ, Pritchard-Jones K, van Heyningen V, Hastie ND. Little MH, et al. Oncogene. 1992 Apr;7(4):635-41. Oncogene. 1992. PMID: 1314367
Zinc finger point mutations within the WT1 gene in Wilms tumor patients.
Little MH, Prosser J, Condie A, Smith PJ, Van Heyningen V, Hastie ND. Little MH, et al. Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):4791-5. doi: 10.1073/pnas.89.11.4791. Proc Natl Acad Sci U S A. 1992. PMID: 1317572 Free PMC article.
A novel target for the Wilms' tumour suppressor protein (WT1) is bound by a unique combination of zinc fingers.
Little MH, Holmes G, Pell L, Caricasole A, Duarte A, Law M, Ward A, Wainwright B. Little MH, et al. Oncogene. 1996 Oct 3;13(7):1461-9. Oncogene. 1996. PMID: 8875984
A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome.
Patek CE, Little MH, Fleming S, Miles C, Charlieu JP, Clarke AR, Miyagawa K, Christie S, Doig J, Harrison DJ, Porteous DJ, Brookes AJ, Hooper ML, Hastie ND. Patek CE, et al. Among authors: little mh. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2931-6. doi: 10.1073/pnas.96.6.2931. Proc Natl Acad Sci U S A. 1999. PMID: 10077614 Free PMC article.
Expression of the vertebrate Slit gene family and their putative receptors, the Robo genes, in the developing murine kidney.
Piper M, Georgas K, Yamada T, Little M. Piper M, et al. Among authors: little m. Mech Dev. 2000 Jun;94(1-2):213-7. doi: 10.1016/s0925-4773(00)00313-0. Mech Dev. 2000. PMID: 10842075
Importantly, both gene families display distinct expression patterns outside the CNS (Holmes, G.P., Negus, K., Burridge, L., Raman, S., Algar, E., Yamada, T., Little, M.H., 1998. Distinct but overlapping expression patterns of two vertebrate slit homologs implies fu …
Importantly, both gene families display distinct expression patterns outside the CNS (Holmes, G.P., Negus, K., Burridge, L., Raman, S., Alga …
Novel WT1 exon 9 mutation (D396Y) in a patient with early onset Denys Drash syndrome.
Little M, Carman G, Donaldson E. Little M, et al. Hum Mutat. 2000 Apr;15(4):389. doi: 10.1002/(SICI)1098-1004(200004)15:4<389::AID-HUMU29>3.0.CO;2-E. Hum Mutat. 2000. PMID: 10738002 No abstract available.
Fine mapping of the neurally expressed gene SOX14 to human 3q23, relative to three congenital diseases.
Hargrave M, James K, Nield K, Toomes C, Georgas K, Sullivan T, Verzijl HT, Oley CA, Little M, De Jonghe P, Kwon JM, Kremer H, Dixon MJ, Timmerman V, Yamada T, Koopman P. Hargrave M, et al. Among authors: little m. Hum Genet. 2000 Apr;106(4):432-9. doi: 10.1007/s004390000266. Hum Genet. 2000. PMID: 10830911
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