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Open randomised trial of prescribing strategies in managing sore throat
Little P, et al. BMJ 1997 - Clinical Trial. PMID 9116551 Free PMC article.
The proportion of patients better by day 3 did not differ significantly (37% v 35% v 30%, P = 0.28), nor did the duration of illness (median 4 v 5 v 5 days, P = 0.39), days off work or school (median 2 v 2 v 1, P = 0.13), or proportion of patients satisfied (96% v 90% v 93%, P = 0.09), although group 1 had fewer days of fever (median 1 v 2 v 2 days, P = 0.04). More patients in group 1 thought the antibiotics were effective (87% v 55% v 60%, P < 0.001) and intended coming to the doctor in future attacks (79% v 54% v 57%, P < 0.001). ...
The proportion of patients better by day 3 did not differ significantly (37% v 35% v 30%, P = 0.28), nor did the duration of illness …
Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media
Little P, et al. BMJ 2001 - Clinical Trial. PMID 11159657 Free PMC article.
Fewer children in the delayed group had diarrhoea (14/150 (9%) v 25/135 (19%), chi(2)=5.2, P=0.02). Fewer parents in the delayed group believed in the effectiveness of antibiotics and in the need to see the doctor with future episodes. ...
Fewer children in the delayed group had diarrhoea (14/150 (9%) v 25/135 (19%), chi(2)=5.2, P=0.02). Fewer parents in the delayed grou …
Randomised controlled trial of self management leaflets and booklets for minor illness provided by post
Little P, et al. BMJ 2001 - Clinical Trial. PMID 11358775 Free PMC article.
More patients in the intervention groups felt greater confidence in managing illness (booklet 32%, card 34%, control 12%, P<0.001), but there was no difference in willingness to wait score (all groups mean=32, P=0.67). ...
More patients in the intervention groups felt greater confidence in managing illness (booklet 32%, card 34%, control 12%, P<0.001) …
Predictors of poor outcome and benefits from antibiotics in children with acute otitis media: pragmatic randomised trial
Little P, et al. BMJ 2002 - Clinical Trial. PMID 12098725 Free PMC article.
In children without higher temperature or vomiting, immediate antibiotics made little difference to distress by day three (15% v 19%, chi2=0.74; P=0.39) or night disturbance (20% v 27%, chi2=1.6; P=0.20). ...CONCLUSION: In children with otitis media but without fever and vomiting antibiotic treatment has little benefit and a poor outcome is unlikely....
In children without higher temperature or vomiting, immediate antibiotics made little difference to distress by day three (15% v 19%, …
A randomised controlled trial of three pragmatic approaches to initiate increased physical activity in sedentary patients with risk factors for cardiovascular disease
Little P, et al. Br J Gen Pract 2004 - Clinical Trial. PMID 15006124 Free PMC article.
There was a trend from the least intensive interventions (control +/- booklet) to the more intensive interventions (prescription and counselling combined +/- booklet) for both increased physical activity and fitness (test for trend, P = 0.02 and P = 0.05, respectively). ...
There was a trend from the least intensive interventions (control +/- booklet) to the more intensive interventions (prescription and counsel …
Randomised controlled factorial trial of dietary advice for patients with a single high blood pressure reading in primary care
Little P, et al. BMJ 2004 - Clinical Trial. PMID 15082472 Free PMC article.
The salt decreased Na:K ratio (difference 0.32; 0.08 to 0.56, P = 0.01), and the prompts helped control weight (difference 0.39 (0.85 to 0.05) kg at one month, P = 0.085; 1.2 (0.1 to 2.25) kg at six months, P = 0.03). Among those with lower fruit and vegetable consumption (< 300 g per day), prompts increased fruit and vegetable consumption and also carotenoid concentrations (difference 143 (16 to 269) mmol/l, P < 0.03) but did not decrease blood pressure. ...
The salt decreased Na:K ratio (difference 0.32; 0.08 to 0.56, P = 0.01), and the prompts helped control weight (difference 0.39 (0.85 …
Longer term outcomes from a randomised trial of prescribing strategies in otitis media
Little P, et al. Br J Gen Pract 2006 - Clinical Trial. PMID 16536957 Free PMC article.
The number of prior episodes of AOM documented in the doctor's notes predicted episodes of earache reported (0, 1, > or = 2 episodes, respectively; OR = 1, 2.42, 2.61; chi2 for trend 8.04; P<0.01). There was weaker evidence that prior episodes also predicted poor function at 1 year (OR = 1, 1.86, 2.28; chi2 for trend 5.49; P = 0.019). ...
The number of prior episodes of AOM documented in the doctor's notes predicted episodes of earache reported (0, 1, > or = 2 episodes, res …
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