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Hedgehog signalling in the mouse requires intraflagellar transport proteins.
Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV. Huangfu D, et al. Among authors: liu a. Nature. 2003 Nov 6;426(6962):83-7. doi: 10.1038/nature02061. Nature. 2003. PMID: 14603322
Both mutations disrupt IFT proteins: the wim mutation is an allele of the previously uncharacterized mouse homologue of IFT172; and fxo is a new hypomorphic allele of polaris, the mouse homologue of IFT88. Genetic analysis shows that Wim, Polaris and the IFT motor protein …
Both mutations disrupt IFT proteins: the wim mutation is an allele of the previously uncharacterized mouse homologue of IFT172; and fxo is …
FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors.
Liu A, Li JY, Bromleigh C, Lao Z, Niswander LA, Joyner AL. Liu A, et al. Development. 2003 Dec;130(25):6175-85. doi: 10.1242/dev.00845. Epub 2003 Nov 5. Development. 2003. PMID: 14602678
The mechanism by which each FGF contributes to patterning the midbrain, and induces a cerebellum in rhombomere 1 (r1) is not clear. We and others have found that FGF8b can transform the midbrain into a cerebellum fate, whereas FGF8a can promote midbrain development. …
The mechanism by which each FGF contributes to patterning the midbrain, and induces a cerebellum in rhombomere 1 (r1) is not clear. W …
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors.
Liu A, Wang B, Niswander LA. Liu A, et al. Development. 2005 Jul;132(13):3103-11. doi: 10.1242/dev.01894. Epub 2005 Jun 1. Development. 2005. PMID: 15930098
The developing limb provides an excellent system to study Hh signaling, in particular as it allows a biological and molecular readout of both Gli activator and repressor function. Here we report that homozygous mutants for flexo (Fxo), a hypomorphic allele of mouse …
The developing limb provides an excellent system to study Hh signaling, in particular as it allows a biological and molecular readout …
Bone morphogenetic protein signalling and vertebrate nervous system development.
Liu A, Niswander LA. Liu A, et al. Nat Rev Neurosci. 2005 Dec;6(12):945-54. doi: 10.1038/nrn1805. Nat Rev Neurosci. 2005. PMID: 16340955 Review.
Experimental embryology and genetics performed in a range of organisms are providing insights into how BMPs establish the neural tissue and control the types and numbers of neurons formed. These studies also highlight the interactions between different developmental signal …
Experimental embryology and genetics performed in a range of organisms are providing insights into how BMPs establish the neural tiss …
C2cd3 is required for cilia formation and Hedgehog signaling in mouse.
Hoover AN, Wynkoop A, Zeng H, Jia J, Niswander LA, Liu A. Hoover AN, et al. Among authors: liu a. Development. 2008 Dec;135(24):4049-58. doi: 10.1242/dev.029835. Epub 2008 Nov 12. Development. 2008. PMID: 19004860 Free PMC article.
Taking a forward genetic approach, we have identified Hearty (Hty), a recessive lethal mouse mutant with multiple defects, including neural tube defects, abnormal dorsal-ventral patterning of the spinal cord, a defect in left-right axis determination and seve …
Taking a forward genetic approach, we have identified Hearty (Hty), a recessive lethal mouse mutant with multiple defects, inc …
Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia.
Jia J, Kolterud A, Zeng H, Hoover A, Teglund S, Toftgård R, Liu A. Jia J, et al. Among authors: liu a. Dev Biol. 2009 Jun 15;330(2):452-60. doi: 10.1016/j.ydbio.2009.04.009. Epub 2009 Apr 14. Dev Biol. 2009. PMID: 19371734 Free PMC article.
Planar cell polarity effector gene Fuzzy regulates cilia formation and Hedgehog signal transduction in mouse.
Heydeck W, Zeng H, Liu A. Heydeck W, et al. Among authors: liu a. Dev Dyn. 2009 Dec;238(12):3035-42. doi: 10.1002/dvdy.22130. Dev Dyn. 2009. PMID: 19877275
A group of core-PCP proteins are recognized to play crucial roles in convergent extension and other PCP-related processes in mammals. ...Finally, a significant decrease in cilia was found in Fuz homozygous mutants. In conclusion, Fuz plays an important role in cilia
A group of core-PCP proteins are recognized to play crucial roles in convergent extension and other PCP-related processes in mammals.
PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals.
Zeng H, Hoover AN, Liu A. Zeng H, et al. Among authors: liu a. Dev Biol. 2010 Mar 15;339(2):418-28. doi: 10.1016/j.ydbio.2010.01.003. Epub 2010 Jan 11. Dev Biol. 2010. PMID: 20067783
In order to understand the roles for Inturned in mammalian embryonic development, we generated a null mutant allele for the mouse homologue of Inturned (Intu) via gene-targeting in ES cells. ...Finally, a cytoplasmic GFP-Intu fusion protein efficiently rescues the c …
In order to understand the roles for Inturned in mammalian embryonic development, we generated a null mutant allele for the mouse hom …
Analysis of hedgehog signaling in mouse intraflagellar transport mutants.
Ko HW, Liu A, Eggenschwiler JT. Ko HW, et al. Among authors: liu a. Methods Cell Biol. 2009;93:347-69. doi: 10.1016/S0091-679X(08)93017-X. Epub 2009 Dec 4. Methods Cell Biol. 2009. PMID: 20409825 Free PMC article.
More recently, IFT has been investigated using genetic approaches in mammals using the mouse as a model system. Through such studies, a new appreciation of the importance of IFT and cilia in mammalian signal transduction has emerged. ...For this reason, we provide …
More recently, IFT has been investigated using genetic approaches in mammals using the mouse as a model system. Through such studies, …
PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube.
Heydeck W, Liu A. Heydeck W, et al. Among authors: liu a. Dev Dyn. 2011 Aug;240(8):1938-48. doi: 10.1002/dvdy.22696. Dev Dyn. 2011. PMID: 21761479
Furthermore, it remains unclear whether mouse Intu and Fuz play a role in convergent extension, a process regulated by PCP signaling. ...Finally, we show in Intu; Fuz double mutants that the lack of convergent extension and more severe patterning defects in Intu and …
Furthermore, it remains unclear whether mouse Intu and Fuz play a role in convergent extension, a process regulated by PCP sig …
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