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mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.
Kim SJ, DeStefano MA, Oh WJ, Wu CC, Vega-Cotto NM, Finlan M, Liu D, Su B, Jacinto E. Kim SJ, et al. Mol Cell. 2012 Dec 28;48(6):875-87. doi: 10.1016/j.molcel.2012.09.029. Epub 2012 Nov 8. Mol Cell. 2012. PMID: 23142081 Free PMC article.
Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.
Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B. Lazorchak AS, et al. Mol Cell. 2010 Aug 13;39(3):433-43. doi: 10.1016/j.molcel.2010.07.031. Mol Cell. 2010. PMID: 20705244 Free PMC article.
Sin1 deficiency results in increased IL-7 receptor (il7r) and RAG recombinase (rag1 and rag2) gene expression, leading to enhanced pro-B cell survival and augmented V(D)J recombinase activity. ...Finally, we demonstrate that the mTOR inhibitor rapamycin induces rag express …
Sin1 deficiency results in increased IL-7 receptor (il7r) and RAG recombinase (rag1 and rag2) gene expression, leading to enhanced pro-B cel …
Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W. Liu P, et al. Nat Cell Biol. 2019 May;21(5):662-663. doi: 10.1038/s41556-019-0280-y. Nat Cell Biol. 2019. PMID: 30783264
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W. Liu P, et al. Nat Cell Biol. 2013 Nov;15(11):1340-50. doi: 10.1038/ncb2860. Epub 2013 Oct 27. Nat Cell Biol. 2013. PMID: 24161930 Free PMC article.
Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2.
Ouyang X, Han Y, Qu G, Li M, Wu N, Liu H, Arojo O, Sun H, Liu X, Liu D, Chen L, Zou Q, Su B. Ouyang X, et al. J Mol Cell Biol. 2019 Feb 1;11(2):93-106. doi: 10.1093/jmcb/mjy065. J Mol Cell Biol. 2019. PMID: 30428057 Free PMC article.
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