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Designed peptides that assemble into cross-α amyloid-like structures.
Zhang SQ, Huang H, Yang J, Kratochvil HT, Lolicato M, Liu Y, Shu X, Liu L, DeGrado WF. Zhang SQ, et al. Among authors: liu y, liu l. Nat Chem Biol. 2018 Sep;14(9):870-875. doi: 10.1038/s41589-018-0105-5. Epub 2018 Jul 30. Nat Chem Biol. 2018. PMID: 30061717 Free PMC article.
X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance.
Thomaston JL, Konstantinidi A, Liu L, Lambrinidis G, Tan J, Caffrey M, Wang J, Degrado WF, Kolocouris A. Thomaston JL, et al. Among authors: liu l. Biochemistry. 2020 Feb 4;59(4):627-634. doi: 10.1021/acs.biochem.9b00971. Epub 2020 Jan 13. Biochemistry. 2020. PMID: 31894969 Free PMC article.
Allosteric cooperation in a de novo-designed two-domain protein.
Pirro F, Schmidt N, Lincoff J, Widel ZX, Polizzi NF, Liu L, Therien MJ, Grabe M, Chino M, Lombardi A, DeGrado WF. Pirro F, et al. Among authors: liu l. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33246-33253. doi: 10.1073/pnas.2017062117. Epub 2020 Dec 14. Proc Natl Acad Sci U S A. 2020. PMID: 33318174 Free PMC article.
Constructing ion channels from water-soluble α-helical barrels.
Scott AJ, Niitsu A, Kratochvil HT, Lang EJM, Sengel JT, Dawson WM, Mahendran KR, Mravic M, Thomson AR, Brady RL, Liu L, Mulholland AJ, Bayley H, DeGrado WF, Wallace MI, Woolfson DN. Scott AJ, et al. Among authors: liu l. Nat Chem. 2021 Jul;13(7):643-650. doi: 10.1038/s41557-021-00688-0. Epub 2021 May 10. Nat Chem. 2021. PMID: 33972753 Free PMC article.
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