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(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization.
Gopalakrishnan M, Buckner SA, Whiteaker KL, Shieh CC, Molinari EJ, Milicic I, Daza AV, Davis-Taber R, Scott VE, Sellers D, Chess-Williams R, Chapple CR, Liu Y, Liu D, Brioni JD, Sullivan JP, Williams M, Carroll WA, Coghlan MJ. Gopalakrishnan M, et al. J Pharmacol Exp Ther. 2002 Oct;303(1):379-86. doi: 10.1124/jpet.102.034538. J Pharmacol Exp Ther. 2002. PMID: 12235274
Molecular identification and functional characterization of a temperature-sensitive transient receptor potential channel (TRPM8) from canine.
Liu Y, Lubin ML, Reitz TL, Wang Y, Colburn RW, Flores CM, Qin N. Liu Y, et al. Eur J Pharmacol. 2006 Jan 13;530(1-2):23-32. doi: 10.1016/j.ejphar.2005.11.033. Epub 2005 Dec 28. Eur J Pharmacol. 2006. PMID: 16386244
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
Jarvis MF, Honore P, Shieh CC, Chapman M, Joshi S, Zhang XF, Kort M, Carroll W, Marron B, Atkinson R, Thomas J, Liu D, Krambis M, Liu Y, McGaraughty S, Chu K, Roeloffs R, Zhong C, Mikusa JP, Hernandez G, Gauvin D, Wade C, Zhu C, Pai M, Scanio M, Shi L, Drizin I, Gregg R, Matulenko M, Hakeem A, Gross M, Johnson M, Marsh K, Wagoner PK, Sullivan JP, Faltynek CR, Krafte DS. Jarvis MF, et al. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8520-5. doi: 10.1073/pnas.0611364104. Epub 2007 May 2. Proc Natl Acad Sci U S A. 2007. PMID: 17483457 Free PMC article.
Carisbamate, a novel neuromodulator, inhibits voltage-gated sodium channels and action potential firing of rat hippocampal neurons.
Liu Y, Yohrling GJ, Wang Y, Hutchinson TL, Brenneman DE, Flores CM, Zhao B. Liu Y, et al. Epilepsy Res. 2009 Jan;83(1):66-72. doi: 10.1016/j.eplepsyres.2008.09.006. Epub 2008 Nov 14. Epilepsy Res. 2009. PMID: 19013768
QPatch: the missing link between HTS and ion channel drug discovery.
Mathes C, Friis S, Finley M, Liu Y. Mathes C, et al. Comb Chem High Throughput Screen. 2009 Jan;12(1):78-95. doi: 10.2174/138620709787047948. Comb Chem High Throughput Screen. 2009. PMID: 19149494 Review.
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain.
Scanio MJ, Shi L, Drizin I, Gregg RJ, Atkinson RN, Thomas JB, Johnson MS, Chapman ML, Liu D, Krambis MJ, Liu Y, Shieh CC, Zhang X, Simler GH, Joshi S, Honore P, Marsh KC, Knox A, Werness S, Antonio B, Krafte DS, Jarvis MF, Faltynek CR, Marron BE, Kort ME. Scanio MJ, et al. Bioorg Med Chem. 2010 Nov 15;18(22):7816-25. doi: 10.1016/j.bmc.2010.09.057. Epub 2010 Sep 29. Bioorg Med Chem. 2010. PMID: 20965738
An integrated multiassay approach to the discovery of small-molecule N-type voltage-gated calcium channel antagonists.
Finley MF, Lubin ML, Neeper MP, Beck E, Liu Y, Flores CM, Qin N. Finley MF, et al. Assay Drug Dev Technol. 2010 Dec;8(6):685-94. doi: 10.1089/adt.2010.0311. Epub 2010 Nov 4. Assay Drug Dev Technol. 2010. PMID: 21050074
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