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The effect of Fc glycan forms on human IgG2 antibody clearance in humans.
Chen X, Liu YD, Flynn GC. Chen X, et al. Among authors: liu yd. Glycobiology. 2009 Mar;19(3):240-9. doi: 10.1093/glycob/cwn120. Epub 2008 Oct 30. Glycobiology. 2009. PMID: 18974198
Effect of high mannose glycan pairing on IgG antibody clearance.
Liu YD, Flynn GC. Liu YD, et al. Biologicals. 2016 May;44(3):163-9. doi: 10.1016/j.biologicals.2016.02.003. Epub 2016 Mar 15. Biologicals. 2016. PMID: 26992607
Investigation of antibody disulfide reduction and re-oxidation and impact to biological activities.
Wang T, Liu YD, Cai B, Huang G, Flynn GC. Wang T, et al. Among authors: liu yd. J Pharm Biomed Anal. 2015 Jan;102:519-28. doi: 10.1016/j.jpba.2014.10.023. Epub 2014 Oct 31. J Pharm Biomed Anal. 2015. PMID: 25459952
Protected hinge in the immunoglobulin G2-A2 disulfide isoform.
Liu YD, Chou RY, Dillon TM, Poppe L, Spahr C, Shi SD, Flynn GC. Liu YD, et al. Protein Sci. 2014 Dec;23(12):1753-64. doi: 10.1002/pro.2557. Epub 2014 Oct 23. Protein Sci. 2014. PMID: 25264323 Free PMC article.
Monoclonal antibody disulfide reduction during manufacturing: Untangling process effects from product effects.
Hutterer KM, Hong RW, Lull J, Zhao X, Wang T, Pei R, Le ME, Borisov O, Piper R, Liu YD, Petty K, Apostol I, Flynn GC. Hutterer KM, et al. Among authors: liu yd. MAbs. 2013 Jul-Aug;5(4):608-13. doi: 10.4161/mabs.24725. Epub 2013 Apr 18. MAbs. 2013. PMID: 23751615 Free PMC article.
IgG2 disulfide isoform conversion kinetics.
Liu YD, Wang T, Chou R, Chen L, Kannan G, Stevenson R, Goetze AM, Jiang XG, Huang G, Dillon TM, Flynn GC. Liu YD, et al. Mol Immunol. 2013 Jun;54(2):217-26. doi: 10.1016/j.molimm.2012.12.005. Epub 2013 Jan 2. Mol Immunol. 2013. PMID: 23291144
Interchain disulfide bonding in human IgG2 antibodies probed by site-directed mutagenesis.
Allen MJ, Guo A, Martinez T, Han M, Flynn GC, Wypych J, Liu YD, Shen WD, Dillon TM, Vezina C, Balland A. Allen MJ, et al. Among authors: liu yd. Biochemistry. 2009 May 5;48(17):3755-66. doi: 10.1021/bi8022174. Biochemistry. 2009. PMID: 19254029
Human IgG2 antibodies display disulfide-mediated structural isoforms.
Wypych J, Li M, Guo A, Zhang Z, Martinez T, Allen MJ, Fodor S, Kelner DN, Flynn GC, Liu YD, Bondarenko PV, Ricci MS, Dillon TM, Balland A. Wypych J, et al. Among authors: liu yd. J Biol Chem. 2008 Jun 6;283(23):16194-205. doi: 10.1074/jbc.M709987200. Epub 2008 Mar 13. J Biol Chem. 2008. PMID: 18339624 Free PMC article.
Structural and functional characterization of disulfide isoforms of the human IgG2 subclass.
Dillon TM, Ricci MS, Vezina C, Flynn GC, Liu YD, Rehder DS, Plant M, Henkle B, Li Y, Deechongkit S, Varnum B, Wypych J, Balland A, Bondarenko PV. Dillon TM, et al. Among authors: liu yd. J Biol Chem. 2008 Jun 6;283(23):16206-15. doi: 10.1074/jbc.M709988200. Epub 2008 Mar 12. J Biol Chem. 2008. PMID: 18339626 Free PMC article.
Rates and impact of human antibody glycation in vivo.
Goetze AM, Liu YD, Arroll T, Chu L, Flynn GC. Goetze AM, et al. Among authors: liu yd. Glycobiology. 2012 Feb;22(2):221-34. doi: 10.1093/glycob/cwr141. Epub 2011 Sep 19. Glycobiology. 2012. PMID: 21930650
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