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339 results
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Human antibody Fc deamidation in vivo.
Liu YD, van Enk JZ, Flynn GC. Liu YD, et al. Biologicals. 2009 Oct;37(5):313-22. doi: 10.1016/j.biologicals.2009.06.001. Epub 2009 Jul 15. Biologicals. 2009. PMID: 19608432 Clinical Trial.
Effect of high mannose glycan pairing on IgG antibody clearance.
Liu YD, Flynn GC. Liu YD, et al. Biologicals. 2016 May;44(3):163-9. doi: 10.1016/j.biologicals.2016.02.003. Epub 2016 Mar 15. Biologicals. 2016. PMID: 26992607
Investigation of antibody disulfide reduction and re-oxidation and impact to biological activities.
Wang T, Liu YD, Cai B, Huang G, Flynn GC. Wang T, et al. Among authors: liu yd. J Pharm Biomed Anal. 2015 Jan;102:519-28. doi: 10.1016/j.jpba.2014.10.023. Epub 2014 Oct 31. J Pharm Biomed Anal. 2015. PMID: 25459952
Monoclonal antibody disulfide reduction during manufacturing: Untangling process effects from product effects.
Hutterer KM, Hong RW, Lull J, Zhao X, Wang T, Pei R, Le ME, Borisov O, Piper R, Liu YD, Petty K, Apostol I, Flynn GC. Hutterer KM, et al. Among authors: liu yd. MAbs. 2013 Jul-Aug;5(4):608-13. doi: 10.4161/mabs.24725. Epub 2013 Apr 18. MAbs. 2013. PMID: 23751615 Free PMC article.
IgG2 disulfide isoform conversion kinetics.
Liu YD, Wang T, Chou R, Chen L, Kannan G, Stevenson R, Goetze AM, Jiang XG, Huang G, Dillon TM, Flynn GC. Liu YD, et al. Mol Immunol. 2013 Jun;54(2):217-26. doi: 10.1016/j.molimm.2012.12.005. Epub 2013 Jan 2. Mol Immunol. 2013. PMID: 23291144
Human IgG2 antibodies display disulfide-mediated structural isoforms.
Wypych J, Li M, Guo A, Zhang Z, Martinez T, Allen MJ, Fodor S, Kelner DN, Flynn GC, Liu YD, Bondarenko PV, Ricci MS, Dillon TM, Balland A. Wypych J, et al. Among authors: liu yd. J Biol Chem. 2008 Jun 6;283(23):16194-205. doi: 10.1074/jbc.M709987200. Epub 2008 Mar 13. J Biol Chem. 2008. PMID: 18339624 Free PMC article.
Structural and functional characterization of disulfide isoforms of the human IgG2 subclass.
Dillon TM, Ricci MS, Vezina C, Flynn GC, Liu YD, Rehder DS, Plant M, Henkle B, Li Y, Deechongkit S, Varnum B, Wypych J, Balland A, Bondarenko PV. Dillon TM, et al. Among authors: liu yd. J Biol Chem. 2008 Jun 6;283(23):16206-15. doi: 10.1074/jbc.M709988200. Epub 2008 Mar 12. J Biol Chem. 2008. PMID: 18339626 Free PMC article.
Rates and impact of human antibody glycation in vivo.
Goetze AM, Liu YD, Arroll T, Chu L, Flynn GC. Goetze AM, et al. Among authors: liu yd. Glycobiology. 2012 Feb;22(2):221-34. doi: 10.1093/glycob/cwr141. Epub 2011 Sep 19. Glycobiology. 2012. PMID: 21930650
High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans.
Goetze AM, Liu YD, Zhang Z, Shah B, Lee E, Bondarenko PV, Flynn GC. Goetze AM, et al. Among authors: liu yd. Glycobiology. 2011 Jul;21(7):949-59. doi: 10.1093/glycob/cwr027. Epub 2011 Mar 18. Glycobiology. 2011. PMID: 21421994
N-terminal glutamate to pyroglutamate conversion in vivo for human IgG2 antibodies.
Liu YD, Goetze AM, Bass RB, Flynn GC. Liu YD, et al. J Biol Chem. 2011 Apr 1;286(13):11211-7. doi: 10.1074/jbc.M110.185041. Epub 2011 Jan 31. J Biol Chem. 2011. PMID: 21282104 Free PMC article.
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