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Ligands regulate cell surface level of the human kappa opioid receptor by activation-induced down-regulation and pharmacological chaperone-mediated enhancement: differential effects of nonpeptide and peptide agonists.
Chen Y, Chen C, Wang Y, Liu-Chen LY. Chen Y, et al. J Pharmacol Exp Ther. 2006 Nov;319(2):765-75. doi: 10.1124/jpet.106.107987. Epub 2006 Aug 1. J Pharmacol Exp Ther. 2006. PMID: 16882876
Molecular basis of differences in (-)(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidiny)-cyclohexyl]benzeneacetamide-induced desensitization and phosphorylation between human and rat kappa-opioid receptors expressed in Chinese hamster ovary cells.
Li J, Li JG, Chen C, Zhang F, Liu-Chen LY. Li J, et al. Mol Pharmacol. 2002 Jan;61(1):73-84. doi: 10.1124/mol.61.1.73. Mol Pharmacol. 2002. PMID: 11752208
Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate.
Li JG, Chen C, Liu-Chen LY. Li JG, et al. J Biol Chem. 2002 Jul 26;277(30):27545-52. doi: 10.1074/jbc.M200058200. Epub 2002 May 9. J Biol Chem. 2002. PMID: 12004055
(-)U50,488H [(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide] induces internalization and down-regulation of the human, but not the rat, kappa-opioid receptor: structural basis for the differential regulation.
Zhang F, Li J, Li JG, Liu-Chen LY. Zhang F, et al. J Pharmacol Exp Ther. 2002 Sep;302(3):1184-92. doi: 10.1124/jpet.302.3.1184. J Pharmacol Exp Ther. 2002. PMID: 12183679
The local environment at the cytoplasmic end of TM6 of the mu opioid receptor differs from those of rhodopsin and monoamine receptors: introduction of an ionic lock between the cytoplasmic ends of helices 3 and 6 by a L6.30(275)E mutation inactivates the mu opioid receptor and reduces the constitutive activity of its T6.34(279)K mutant.
Huang P, Visiers I, Weinstein H, Liu-Chen LY. Huang P, et al. Biochemistry. 2002 Oct 8;41(40):11972-80. doi: 10.1021/bi026067b. Biochemistry. 2002. PMID: 12356297
Differential regulation of the human kappa opioid receptor by agonists: etorphine and levorphanol reduced dynorphin A- and U50,488H-induced internalization and phosphorylation.
Li JG, Zhang F, Jin XL, Liu-Chen LY. Li JG, et al. J Pharmacol Exp Ther. 2003 May;305(2):531-40. doi: 10.1124/jpet.102.045559. Epub 2003 Jan 24. J Pharmacol Exp Ther. 2003. PMID: 12606694
Selective inactivation of CCR5 and decreased infectivity of R5 HIV-1 strains mediated by opioid-induced heterologous desensitization.
Szabo I, Wetzel MA, Zhang N, Steele AD, Kaminsky DE, Chen C, Liu-Chen LY, Bednar F, Henderson EE, Howard OM, Oppenheim JJ, Rogers TJ. Szabo I, et al. J Leukoc Biol. 2003 Dec;74(6):1074-82. doi: 10.1189/jlb.0203067. Epub 2003 Sep 12. J Leukoc Biol. 2003. PMID: 12972507
Differential effects of agonists on adenylyl cyclase superactivation mediated by the kappa opioid receptors: adenylyl cyclase superactivation is independent of agonist-induced phosphorylation, desensitization, internalization, and down-regulation.
Wang Y, Li JG, Huang P, Xu W, Liu-Chen LY. Wang Y, et al. J Pharmacol Exp Ther. 2003 Dec;307(3):1127-34. doi: 10.1124/jpet.103.055814. Epub 2003 Oct 13. J Pharmacol Exp Ther. 2003. PMID: 14557376
Heterodimerization and cross-desensitization between the mu-opioid receptor and the chemokine CCR5 receptor.
Chen C, Li J, Bot G, Szabo I, Rogers TJ, Liu-Chen LY. Chen C, et al. Eur J Pharmacol. 2004 Jan 12;483(2-3):175-86. doi: 10.1016/j.ejphar.2003.10.033. Eur J Pharmacol. 2004. PMID: 14729105
kappa Opioid receptor interacts with Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na(+)/H(+) exchange independent of G(i)/G(o) proteins.
Huang P, Steplock D, Weinman EJ, Hall RA, Ding Z, Li J, Wang Y, Liu-Chen LY. Huang P, et al. J Biol Chem. 2004 Jun 11;279(24):25002-9. doi: 10.1074/jbc.M313366200. Epub 2004 Apr 7. J Biol Chem. 2004. PMID: 15070904
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