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2024 650
2025 10
2026 0

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660 results

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Page 1
Engineered 3D Immuno-Glial-Neurovascular Human miBrain Model.
Stanton AE, Bubnys A, Agbas E, James B, Park DS, Jiang A, Pinals RL, Liu L, Truong N, Loon A, Staab C, Cerit O, Wen HL, Kellis M, Blanchard JW, Langer R, Tsai LH. Stanton AE, et al. bioRxiv [Preprint]. 2024 Jun 11:2023.08.15.553453. doi: 10.1101/2023.08.15.553453. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2025 Oct 21;122(42):e2511596122. doi: 10.1073/pnas.2511596122. PMID: 37645757 Free PMC article. Updated. Preprint.
A metabolic atlas of mouse aging.
Pilley SE, Awad D, Latumalea D, Esparza E, Zhang L, Shi X, Unfried M, Wang S, Mulondo R, Kashyap SB, Moaddeli D, Sajjakulnukit P, Sutton D, Wong H, Coakley AJ, Garcia G, Higuchi-Sanabria R, Liu S, Yu B, Tu WB, Kennedy BK, Lyssiotis CA, Mullen PJ. Pilley SE, et al. bioRxiv [Preprint]. 2024 May 5:2024.05.04.592445. doi: 10.1101/2024.05.04.592445. bioRxiv. 2024. Update in: Cell Metab. 2025 Nov 25:S1550-4131(25)00476-0. doi: 10.1016/j.cmet.2025.10.016. PMID: 38746230 Free PMC article. Updated. Preprint.
Diffusing protein binders to intrinsically disordered proteins.
Liu C, Wu K, Choi H, Han H, Zhang X, Watson JL, Shijo S, Bera AK, Kang A, Brackenbrough E, Coventry B, Hick DR, Hoofnagle AN, Zhu P, Li X, Decarreau J, Gerben SR, Yang W, Wang X, Lamp M, Murray A, Bauer M, Baker D. Liu C, et al. bioRxiv [Preprint]. 2024 Jul 16:2024.07.16.603789. doi: 10.1101/2024.07.16.603789. bioRxiv. 2024. Update in: Nature. 2025 Aug;644(8077):809-817. doi: 10.1038/s41586-025-09248-9. PMID: 39071267 Free PMC article. Updated. Preprint.
Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity.
Singh S, Gleason CE, Fang M, Laimon YN, Khivansara V, Xie S, Durmaz YT, Sarkar A, Ngo K, Savla V, Li Y, Abu-Remaileh M, Li X, Tuladhar B, Odeh R, Hamkins-Indik F, He D, Membreno MW, Nosrati M, Gushwa NN, Leung SSF, Fraga-Walton B, Hernandez L, Baldomero MP, Lent BM, Spellmeyer D, Luna JF, Hoang D, Gritsenko Y, Chand M, DeMart MK, Metobo S, Bhatt C, Shapiro JA, Yang K, Dupper NJ, Bockus AT, Doench JG, Aggen JB, Liu LF, Levin B, Wang EW, Vendrell I, Fischer R, Kessler B, Gokhale PC, Signoretti S, Spektor A, Kreatsoulas C, Singh R, Earp DJ, Garcia PD, Nijhawan D, Oser MG. Singh S, et al. bioRxiv [Preprint]. 2024 Aug 1:2024.08.01.605889. doi: 10.1101/2024.08.01.605889. bioRxiv. 2024. PMID: 39211113 Free PMC article. Preprint.
Potent antitumor activity of a designed interleukin-21 mimic.
Chun JH, Lim BS, Roy S, Walsh MJ, Abhiraman GC, Zhangxu K, Atajanova T, Revach OY, Clark EC, Li P, Palin CA, Khanna A, Tower S, Kureshi R, Hoffman MT, Sharova T, Lawless A, Cohen S, Boland GM, Nguyen T, Peprah F, Tello JG, Liu SY, Kim CJ, Shin H, Quijano-Rubio A, Jude KM, Gerben S, Murray A, Heine P, DeWitt M, Ulge UY, Carter L, King NP, Silva DA, Kueh HY, Kalia V, Sarkar S, Jenkins RW, Garcia KC, Leonard WJ, Dougan M, Dougan SK, Baker D. Chun JH, et al. bioRxiv [Preprint]. 2024 Dec 7:2024.12.06.626481. doi: 10.1101/2024.12.06.626481. bioRxiv. 2024. PMID: 39677740 Free PMC article. Preprint.
Covalent inhibitors of the RAS binding domain of PI3Kα impair tumor growth driven by RAS and HER2.
Klebba JE, Roy N, Bernard SM, Grabow S, Hoffman MA, Miao H, Tamiya J, Wang J, Berry C, Esparza-Oros A, Lin R, Liu Y, Pariollaud M, Parker H, Mochalkin I, Rana S, Snead AN, Walton EJ, Wyrick TE, Aitichson E, Bedke K, Brannon JC, Chick JM, Hee K, Horning BD, Ismail M, Lamb KN, Lin W, Metzger J, Pastuszka MK, Pollock J, Sigler JJ, Tomaschko M, Tran E, Kinsella TM, Molina-Arcas M, Simon GM, Weinstein DS, Downward J, Patricelli MP. Klebba JE, et al. bioRxiv [Preprint]. 2024 Dec 20:2024.12.17.629001. doi: 10.1101/2024.12.17.629001. bioRxiv. 2024. Update in: Science. 2025 Nov 13;390(6774):702-709. doi: 10.1126/science.adv2684. PMID: 39763752 Free PMC article. Updated. Preprint.
MethylGPT: a foundation model for the DNA methylome.
Ying K, Song J, Cui H, Zhang Y, Li S, Chen X, Liu H, Eames A, McCartney DL, Marioni RE, Poganik JR, Moqri M, Wang B, Gladyshev VN. Ying K, et al. bioRxiv [Preprint]. 2024 Nov 4:2024.10.30.621013. doi: 10.1101/2024.10.30.621013. bioRxiv. 2024. PMID: 39574641 Free PMC article. Preprint.
Cross-species modeling of plant genomes at single nucleotide resolution using a pre-trained DNA language model.
Zhai J, Gokaslan A, Schiff Y, Berthel A, Liu ZY, Lai WY, Miller ZR, Scheben A, Stitzer MC, Romay MC, Buckler ES, Kuleshov V. Zhai J, et al. bioRxiv [Preprint]. 2024 Aug 22:2024.06.04.596709. doi: 10.1101/2024.06.04.596709. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2025 Jun 17;122(24):e2421738122. doi: 10.1073/pnas.2421738122. PMID: 38895432 Free PMC article. Updated. Preprint.
660 results