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Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site.
Chem Biol. 2002 Apr;9(4):455-63. doi: 10.1016/s1074-5521(02)00125-4.
Chem Biol. 2002.
PMID: 11983334
Design of novel antibiotics that bind to the ribosomal acyltransfer site.
Haddad J, Kotra LP, Llano-Sotelo B, Kim C, Azucena EF Jr, Liu M, Vakulenko SB, Chow CS, Mobashery S.
Haddad J, et al. Among authors: llano sotelo b.
J Am Chem Soc. 2002 Apr 3;124(13):3229-37. doi: 10.1021/ja011695m.
J Am Chem Soc. 2002.
PMID: 11916405
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RNA-aminoglycoside antibiotic interactions: fluorescence detection of binding and conformational change.
Llano-Sotelo B, Chow CS.
Llano-Sotelo B, et al.
Bioorg Med Chem Lett. 1999 Jan 18;9(2):213-6. doi: 10.1016/s0960-894x(98)00718-5.
Bioorg Med Chem Lett. 1999.
PMID: 10021931
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Selection of small peptides, inhibitors of translation.
Llano-Sotelo B, Klepacki D, Mankin AS.
Llano-Sotelo B, et al.
J Mol Biol. 2009 Sep 4;391(5):813-9. doi: 10.1016/j.jmb.2009.06.069. Epub 2009 Jul 2.
J Mol Biol. 2009.
PMID: 19576904
Free PMC article.
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Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis.
Llano-Sotelo B, Dunkle J, Klepacki D, Zhang W, Fernandes P, Cate JH, Mankin AS.
Llano-Sotelo B, et al.
Antimicrob Agents Chemother. 2010 Dec;54(12):4961-70. doi: 10.1128/AAC.00860-10. Epub 2010 Sep 20.
Antimicrob Agents Chemother. 2010.
PMID: 20855725
Free PMC article.
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Fluorescently labeled ribosomes as a tool for analyzing antibiotic binding.
Llano-Sotelo B, Hickerson RP, Lancaster L, Noller HF, Mankin AS.
Llano-Sotelo B, et al.
RNA. 2009 Aug;15(8):1597-604. doi: 10.1261/rna.1681609. Epub 2009 Jun 24.
RNA. 2009.
PMID: 19553343
Free PMC article.
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