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Targeting Akt in cancer therapy.
LoPiccolo J, Granville CA, Gills JJ, Dennis PA. LoPiccolo J, et al. Anticancer Drugs. 2007 Sep;18(8):861-74. doi: 10.1097/CAD.0b013e3280cc2c6f. Anticancer Drugs. 2007. PMID: 17667591 Review.
Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo.
Gills JJ, Lopiccolo J, Tsurutani J, Shoemaker RH, Best CJ, Abu-Asab MS, Borojerdi J, Warfel NA, Gardner ER, Danish M, Hollander MC, Kawabata S, Tsokos M, Figg WD, Steeg PS, Dennis PA. Gills JJ, et al. Among authors: lopiccolo j. Clin Cancer Res. 2007 Sep 1;13(17):5183-94. doi: 10.1158/1078-0432.CCR-07-0161. Clin Cancer Res. 2007. PMID: 17785575
A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.
Granville CA, Memmott RM, Balogh A, Mariotti J, Kawabata S, Han W, Lopiccolo J, Foley J, Liewehr DJ, Steinberg SM, Fowler DH, Hollander MC, Dennis PA. Granville CA, et al. Among authors: lopiccolo j. PLoS One. 2009;4(3):e5061. doi: 10.1371/journal.pone.0005061. Epub 2009 Mar 30. PLoS One. 2009. PMID: 19330036 Free PMC article.
A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors.
Blumenthal GM, Gills JJ, Ballas MS, Bernstein WB, Komiya T, Dechowdhury R, Morrow B, Root H, Chun G, Helsabeck C, Steinberg SM, LoPiccolo J, Kawabata S, Gardner ER, Figg WD, Dennis PA. Blumenthal GM, et al. Among authors: lopiccolo j. Oncotarget. 2014 Sep 30;5(18):8161-72. doi: 10.18632/oncotarget.2415. Oncotarget. 2014. PMID: 25327558 Free PMC article. Clinical Trial.
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