Locke WJ - Search Results

1

Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value.

Stirzaker C, Zotenko E, Song JZ, Qu W, Nair SS, Locke WJ, Stone A, Armstong NJ, Robinson MD, Dobrovic A, Avery-Kiejda KA, Peters KM, French JD, Stein S, Korbie DJ, Trau M, Forbes JF, Scott RJ, Brown MA, Francis GD, Clark SJ. Stirzaker C, et al. Among authors: locke wj. Nat Commun. 2015 Feb 2;6:5899. doi: 10.1038/ncomms6899. Nat Commun. 2015. PMID: 25641231 Free article.

2

DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer.

Stone A, Zotenko E, Locke WJ, Korbie D, Millar EK, Pidsley R, Stirzaker C, Graham P, Trau M, Musgrove EA, Nicholson RI, Gee JM, Clark SJ. Stone A, et al. Among authors: locke wj. Nat Commun. 2015 Jul 14;6:7758. doi: 10.1038/ncomms8758. Nat Commun. 2015. PMID: 26169690 Free PMC article.

3

DNA methylation profile of triple negative breast cancer-specific genes comparing lymph node positive patients to lymph node negative patients.

Mathe A, Wong-Brown M, Locke WJ, Stirzaker C, Braye SG, Forbes JF, Clark SJ, Avery-Kiejda KA, Scott RJ. Mathe A, et al. Among authors: locke wj. Sci Rep. 2016 Sep 27;6:33435. doi: 10.1038/srep33435. Sci Rep. 2016. PMID: 27671774 Free PMC article.

4

Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer.

Achinger-Kawecka J, Valdes-Mora F, Luu PL, Giles KA, Caldon CE, Qu W, Nair S, Soto S, Locke WJ, Yeo-Teh NS, Gould CM, Du Q, Smith GC, Ramos IR, Fernandez KF, Hoon DS, Gee JMW, Stirzaker C, Clark SJ. Achinger-Kawecka J, et al. Among authors: locke wj. Nat Commun. 2020 Jan 16;11(1):320. doi: 10.1038/s41467-019-14098-x. Nat Commun. 2020. PMID: 31949157 Free PMC article.

5

Identification of DNA methylation biomarkers with potential to predict response to neoadjuvant chemotherapy in triple-negative breast cancer.

Meyer B, Clifton S, Locke W, Luu PL, Du Q, Lam D, Armstrong NJ, Kumar B, Deng N, Harvey K, Swarbrick A, Ganju V, Clark SJ, Pidsley R, Stirzaker C. Meyer B, et al. Clin Epigenetics. 2021 Dec 18;13(1):226. doi: 10.1186/s13148-021-01210-6. Clin Epigenetics. 2021. PMID: 34922619 Free PMC article.

6

Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis.

Locke WJ, Clark SJ. Locke WJ, et al. Breast Cancer Res. 2012 Nov 15;14(6):215. doi: 10.1186/bcr3237. Breast Cancer Res. 2012. PMID: 23168266 Free PMC article. Review.

7

Coordinated epigenetic remodelling of transcriptional networks occurs during early breast carcinogenesis.

Locke WJ, Zotenko E, Stirzaker C, Robinson MD, Hinshelwood RA, Stone A, Reddel RR, Huschtscha LI, Clark SJ. Locke WJ, et al. Clin Epigenetics. 2015 May 1;7(1):52. doi: 10.1186/s13148-015-0086-0. eCollection 2015. Clin Epigenetics. 2015. PMID: 25960784 Free PMC article.

8

Methyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer.

Stirzaker C, Song JZ, Ng W, Du Q, Armstrong NJ, Locke WJ, Statham AL, French H, Pidsley R, Valdes-Mora F, Zotenko E, Clark SJ. Stirzaker C, et al. Among authors: locke wj. Oncogene. 2017 Mar;36(10):1328-1338. doi: 10.1038/onc.2016.297. Epub 2016 Sep 5. Oncogene. 2017. PMID: 27593931

9

Next-Generation Molecular Discovery: From Bottom-Up In Vivo and In Vitro Approaches to In Silico Top-Down Approaches for Therapeutics Neogenesis.

Kenny SE, Antaw F, Locke WJ, Howard CB, Korbie D, Trau M. Kenny SE, et al. Among authors: locke wj. Life (Basel). 2022 Mar 2;12(3):363. doi: 10.3390/life12030363. Life (Basel). 2022. PMID: 35330114 Free PMC article. Review.

10

A role for GATA-2 in transition to an aggressive phenotype in prostate cancer through modulation of key androgen-regulated genes.

Böhm M, Locke WJ, Sutherland RL, Kench JG, Henshall SM. Böhm M, et al. Among authors: locke wj. Oncogene. 2009 Oct 29;28(43):3847-56. doi: 10.1038/onc.2009.243. Epub 2009 Aug 17. Oncogene. 2009. PMID: 19684615

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