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64 results
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Environmental and occupational causes of cancer: new evidence 2005-2007.
Clapp RW, Jacobs MM, Loechler EL. Clapp RW, et al. Among authors: loechler el. Rev Environ Health. 2008 Jan-Mar;23(1):1-37. doi: 10.1515/reveh.2008.23.1.1. Rev Environ Health. 2008. PMID: 18557596 Free PMC article. Review.
The precautionary principle in environmental science.
Kriebel D, Tickner J, Epstein P, Lemons J, Levins R, Loechler EL, Quinn M, Rudel R, Schettler T, Stoto M. Kriebel D, et al. Among authors: loechler el. Environ Health Perspect. 2001 Sep;109(9):871-6. doi: 10.1289/ehp.01109871. Environ Health Perspect. 2001. PMID: 11673114 Free PMC article.
Toward an understanding of the role of DNA adduct conformation in defining mutagenic mechanism based on studies of the major adduct (formed at N(2)-dG) of the potent environmental carcinogen, benzo[a]pyrene.
Kozack R, Seo KY, Jelinsky SA, Loechler EL. Kozack R, et al. Among authors: loechler el. Mutat Res. 2000 May 30;450(1-2):41-59. doi: 10.1016/s0027-5107(00)00015-4. Mutat Res. 2000. PMID: 10838133 Review.
Mutagenesis studies of the major benzo[a]pyrene N2-dG adduct in a 5'-TG versus a 5'-UG sequence: removal of the methyl group causes a modest decrease in the [G->T/G->A] mutational ratio.
Nagalingam A, Seo KY, Loechler EL. Nagalingam A, et al. Among authors: loechler el. Mutagenesis. 2005 Mar;20(2):105-10. doi: 10.1093/mutage/gei014. Epub 2005 Mar 8. Mutagenesis. 2005. PMID: 15755802
Molecular modeling benzo[a]pyrene N2-dG adducts in the two overlapping active sites of the Y-family DNA polymerase Dpo4.
Chandani S, Loechler EL. Chandani S, et al. Among authors: loechler el. J Mol Graph Model. 2007 Jan;25(5):658-70. doi: 10.1016/j.jmgm.2006.05.003. Epub 2006 May 9. J Mol Graph Model. 2007. PMID: 16782374
Y-Family DNA polymerases may use two different dNTP shapes for insertion: a hypothesis and its implications.
Chandani S, Loechler EL. Chandani S, et al. Among authors: loechler el. J Mol Graph Model. 2009 Apr;27(7):759-69. doi: 10.1016/j.jmgm.2008.11.003. Epub 2008 Nov 8. J Mol Graph Model. 2009. PMID: 19188081 Free PMC article.
Amino acid architecture that influences dNTP insertion efficiency in Y-family DNA polymerase V of E. coli.
Seo KY, Yin J, Donthamsetti P, Chandani S, Lee CH, Loechler EL. Seo KY, et al. Among authors: loechler el. J Mol Biol. 2009 Sep 18;392(2):270-82. doi: 10.1016/j.jmb.2009.07.016. Epub 2009 Jul 14. J Mol Biol. 2009. PMID: 19607844 Free PMC article.
The major, N2-Gua adduct of the (+)-anti-benzo[a]pyrene diol epoxide can be unstable in double-stranded DNA.
Drouin EE, Lech J, Loechler EL. Drouin EE, et al. Among authors: loechler el. Biochemistry. 1995 Feb 21;34(7):2251-9. doi: 10.1021/bi00007a020. Biochemistry. 1995. PMID: 7857936
Mapping the binding site of aflatoxin B1 in DNA: systematic analysis of the reactivity of aflatoxin B1 with guanines in different DNA sequences.
Benasutti M, Ejadi S, Whitlow MD, Loechler EL. Benasutti M, et al. Among authors: loechler el. Biochemistry. 1988 Jan 12;27(1):472-81. doi: 10.1021/bi00401a068. Biochemistry. 1988. PMID: 2831961
Synthesis of a duplex oligonucleotide containing a nitrogen mustard interstrand DNA-DNA cross-link.
Ojwang JO, Grueneberg DA, Loechler EL. Ojwang JO, et al. Among authors: loechler el. Cancer Res. 1989 Dec 1;49(23):6529-37. Cancer Res. 1989. PMID: 2819709
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