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TOR Complexes and the Maintenance of Cellular Homeostasis.
Eltschinger S, Loewith R. Eltschinger S, et al. Among authors: loewith r. Trends Cell Biol. 2016 Feb;26(2):148-159. doi: 10.1016/j.tcb.2015.10.003. Epub 2015 Nov 4. Trends Cell Biol. 2016. PMID: 26546292 Review.
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN. Loewith R, et al. Mol Cell. 2002 Sep;10(3):457-68. doi: 10.1016/s1097-2765(02)00636-6. Mol Cell. 2002. PMID: 12408816
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA, Hall A, Hall MN. Jacinto E, et al. Among authors: loewith r. Nat Cell Biol. 2004 Nov;6(11):1122-8. doi: 10.1038/ncb1183. Epub 2004 Oct 3. Nat Cell Biol. 2004. PMID: 15467718
TOR signaling in growth and metabolism.
Wullschleger S, Loewith R, Hall MN. Wullschleger S, et al. Among authors: loewith r. Cell. 2006 Feb 10;124(3):471-84. doi: 10.1016/j.cell.2006.01.016. Cell. 2006. PMID: 16469695 Review.
The TOR signalling network from yeast to man.
De Virgilio C, Loewith R. De Virgilio C, et al. Among authors: loewith r. Int J Biochem Cell Biol. 2006;38(9):1476-81. doi: 10.1016/j.biocel.2006.02.013. Epub 2006 Mar 9. Int J Biochem Cell Biol. 2006. PMID: 16647875 Review.
Cell growth control: little eukaryotes make big contributions.
De Virgilio C, Loewith R. De Virgilio C, et al. Among authors: loewith r. Oncogene. 2006 Oct 16;25(48):6392-415. doi: 10.1038/sj.onc.1209884. Oncogene. 2006. PMID: 17041625 Review.
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.
Urban J, Soulard A, Huber A, Lippman S, Mukhopadhyay D, Deloche O, Wanke V, Anrather D, Ammerer G, Riezman H, Broach JR, De Virgilio C, Hall MN, Loewith R. Urban J, et al. Among authors: loewith r. Mol Cell. 2007 Jun 8;26(5):663-74. doi: 10.1016/j.molcel.2007.04.020. Mol Cell. 2007. PMID: 17560372
Caffeine extends yeast lifespan by targeting TORC1.
Wanke V, Cameroni E, Uotila A, Piccolis M, Urban J, Loewith R, De Virgilio C. Wanke V, et al. Among authors: loewith r. Mol Microbiol. 2008 Jul;69(1):277-85. doi: 10.1111/j.1365-2958.2008.06292.x. Epub 2008 May 26. Mol Microbiol. 2008. PMID: 18513215
Arsenic toxicity to Saccharomyces cerevisiae is a consequence of inhibition of the TORC1 kinase combined with a chronic stress response.
Hosiner D, Lempiäinen H, Reiter W, Urban J, Loewith R, Ammerer G, Schweyen R, Shore D, Schüller C. Hosiner D, et al. Among authors: loewith r. Mol Biol Cell. 2009 Feb;20(3):1048-57. doi: 10.1091/mbc.e08-04-0438. Epub 2008 Dec 10. Mol Biol Cell. 2009. PMID: 19073887 Free PMC article.
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM. Feldman ME, et al. Among authors: loewith r. PLoS Biol. 2009 Feb 10;7(2):e38. doi: 10.1371/journal.pbio.1000038. PLoS Biol. 2009. PMID: 19209957 Free PMC article.
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