Loewith RJ - Search Results

1

Dual action antifungal small molecule modulates multidrug efflux and TOR signaling.

Shekhar-Guturja T, Gunaherath GM, Wijeratne EM, Lambert JP, Averette AF, Lee SC, Kim T, Bahn YS, Tripodi F, Ammar R, Döhl K, Niewola-Staszkowska K, Schmitt L, Loewith RJ, Roth FP, Sanglard D, Andes D, Nislow C, Coccetti P, Gingras AC, Heitman J, Gunatilaka AA, Cowen LE. Shekhar-Guturja T, et al. Among authors: loewith rj. Nat Chem Biol. 2016 Oct;12(10):867-75. doi: 10.1038/nchembio.2165. Epub 2016 Aug 29. Nat Chem Biol. 2016. PMID: 27571477 Free PMC article.

2

Target of rapamycin (TOR) in nutrient signaling and growth control.

Loewith R, Hall MN. Loewith R, et al. Genetics. 2011 Dec;189(4):1177-201. doi: 10.1534/genetics.111.133363. Genetics. 2011. PMID: 22174183 Free PMC article. Review.

3

A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.

Kennedy MA, Gable K, Niewola-Staszkowska K, Abreu S, Johnston A, Harris LJ, Reggiori F, Loewith R, Dunn T, Bennett SA, Baetz K. Kennedy MA, et al. PLoS Genet. 2014 Jan;10(1):e1004010. doi: 10.1371/journal.pgen.1004010. Epub 2014 Jan 23. PLoS Genet. 2014. PMID: 24465216 Free PMC article.

4

A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.

Kennedy MA, Moffat TC, Gable K, Ganesan S, Niewola-Staszkowska K, Johnston A, Nislow C, Giaever G, Harris LJ, Loewith R, Zaremberg V, Harper ME, Dunn T, Bennett SAL, Baetz K. Kennedy MA, et al. Sci Rep. 2016 Jan 13;6:19332. doi: 10.1038/srep19332. Sci Rep. 2016. PMID: 26757638 Free PMC article.

5

Decrease in plasma membrane tension triggers PtdIns(4,5)P₂ phase separation to inactivate TORC2.

Riggi M, Niewola-Staszkowska K, Chiaruttini N, Colom A, Kusmider B, Mercier V, Soleimanpour S, Stahl M, Matile S, Roux A, Loewith R. Riggi M, et al. Nat Cell Biol. 2018 Sep;20(9):1043-1051. doi: 10.1038/s41556-018-0150-z. Epub 2018 Aug 27. Nat Cell Biol. 2018. PMID: 30154550 Free PMC article.

6

Dynamic metabolome profiling uncovers potential TOR signaling genes.

Reichling S, Doubleday PF, Germade T, Bergmann A, Loewith R, Sauer U, Holbrook-Smith D. Reichling S, et al. Elife. 2023 Jan 4;12:e84295. doi: 10.7554/eLife.84295. Elife. 2023. PMID: 36598488 Free PMC article.

7

TOR signaling in growth and metabolism.

Wullschleger S, Loewith R, Hall MN. Wullschleger S, et al. Cell. 2006 Feb 10;124(3):471-84. doi: 10.1016/j.cell.2006.01.016. Cell. 2006. PMID: 16469695 Free article. Review.

8

The TOR signalling network from yeast to man.

De Virgilio C, Loewith R. De Virgilio C, et al. Int J Biochem Cell Biol. 2006;38(9):1476-81. doi: 10.1016/j.biocel.2006.02.013. Epub 2006 Mar 9. Int J Biochem Cell Biol. 2006. PMID: 16647875 Review.

9

Caffeine extends yeast lifespan by targeting TORC1.

Wanke V, Cameroni E, Uotila A, Piccolis M, Urban J, Loewith R, De Virgilio C. Wanke V, et al. Mol Microbiol. 2008 Jul;69(1):277-85. doi: 10.1111/j.1365-2958.2008.06292.x. Epub 2008 May 26. Mol Microbiol. 2008. PMID: 18513215 Free article.

10

Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling.

Lempiäinen H, Uotila A, Urban J, Dohnal I, Ammerer G, Loewith R, Shore D. Lempiäinen H, et al. Mol Cell. 2009 Mar 27;33(6):704-16. doi: 10.1016/j.molcel.2009.01.034. Mol Cell. 2009. PMID: 19328065 Free article.

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